UniProt Accession

 MMP19_MOUSE; Q9JHI0; Q8C360 

Genbank Protein ID

 AF155221; AF162446; AF153199; AK086808 

Genbank Nucleotide ID

 AAF73292.1; AAF80464.1; AAG29880.1; BAC39747.1 

Protein Name

 Matrix metalloproteinase-19 

Protein Synonyms/Alias

 MMP-19; Matrix metalloproteinase RASI 

Gene Name

 Mmp19 

Gene Synonyms/Alias

 Rasi 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
258	GIQALYGKRSPETRD	ubiquitination	[1]
372	MSPGFPMKFNRVEPN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity). Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity). 

Sequence Annotation

 REPEAT 286 333 Hemopexin 1.
 REPEAT 334 372 Hemopexin 2.
 REPEAT 377 425 Hemopexin 3.
 REPEAT 426 471 Hemopexin 4.
 MOTIF 84 91 Cysteine switch (By similarity).
 ACT_SITE 214 214 By similarity.
 METAL 86 86 Zinc; in inhibited form (By similarity).
 METAL 213 213 Zinc; catalytic (By similarity).
 METAL 217 217 Zinc; catalytic (By similarity).
 METAL 223 223 Zinc; catalytic (By similarity).
 LIPID 512 512 GPI-anchor amidated aspartate
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 464 464 N-linked (GlcNAc...) (Potential).
 CARBOHYD 479 479 N-linked (GlcNAc...) (Potential).
 CARBOHYD 521 521 N-linked (GlcNAc...) (Potential).
 DISULFID 289 471 By similarity.  

Keyword

 Angiogenesis; Calcium; Cell membrane; Collagen degradation; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Extracellular matrix; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Membrane; Metal-binding; Metalloprotease; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 527 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; ISS:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.
 GO:0001554; P:luteolysis; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0001542; P:ovulation from ovarian follicle; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001818; Pept_M10_metallopeptidase.
 IPR021190; Pept_M10A.
 IPR016293; Pept_M10A_Metazoans.
 IPR006026; Peptidase_Metallo.
 IPR002477; Peptidoglycan-bd-like. 

Pfam

 PF00045; Hemopexin
 PF00413; Peptidase_M10
 PF01471; PG_binding_1 

SMART

 SM00120; HX
 SM00235; ZnMc 

PROSITE

 PS00546; CYSTEINE_SWITCH
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00142; ZINC_PROTEASE 

PRINTS

 PR00138; MATRIXIN.