CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004017
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 2, facilitated glucose transporter member 2 
Protein Synonyms/Alias
 Glucose transporter type 2, liver; GLUT-2 
Gene Name
 Slc2a2 
Gene Synonyms/Alias
 Glut-2; Glut2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
499EIAAEFRKKSGSAPPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. 
Sequence Annotation
 MOD_RES 519 519 Phosphoserine (By similarity).
 CARBOHYD 62 62 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 522 AA 
Protein Sequence
MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL DDRRATINYD 60
INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS SFAVGGMVAS FFGGWLGDKL 120
GRIKAMLAAN SLSLTGALLM GCSKFGPAHA LIIAGRSVSG LYCGLISGLV PMYIGEIAPT 180
TLRGALGTLH QLALVTGILI SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES 240
PRYLYLNLEE EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ 300
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF TAVSVLLVEK 360
AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT AIFLFVSFFE IGPGPIPWFM 420
VAEFFSQGPR PTALALAAFS NWVCNFIIAL CFQYIADFLG PYVFFLFAGV VLVFTLFTFF 480
KVPETKGKSF DEIAAEFRKK SGSAPPRKAT VQMEFLGSSE TV 522 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:RGD.
 GO:0031526; C:brush border membrane; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005768; C:endosome; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB.
 GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB.
 GO:0009758; P:carbohydrate utilization; IMP:RGD.
 GO:0015755; P:fructose transport; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. 
Interpro
 IPR002440; Glc_transpt_2.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR01191; GLUCTRSPORT2.
 PR00171; SUGRTRNSPORT.