UniProt Accession

 6PGL_ECOLI; P52697; P75760 

Genbank Protein ID

 U27192; U00096; AP009048 

Genbank Nucleotide ID

 AAC73854.1; BAA35431.1 

Protein Name

 6-phosphogluconolactonase 

Protein Synonyms/Alias

 6-P-gluconolactonase; Pgl 

Gene Name

 pgl 

Gene Synonyms/Alias

 ybhE; b0767; JW0750 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
147	TLWVPALKQDRICLF	acetylation	[1, 2]
287	FNVDHSGKYLIAAGQ	acetylation	[2, 3]
314	EQGLLHEKGRYAVGQ	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. 

Sequence Annotation

 MOD_RES 287 287 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0017057; F:6-phosphogluconolactonase activity; IDA:EcoliWiki.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 

Interpro

 IPR022528; 6-phosphogluconolactonase_YbhE.
 IPR019405; Lactonase_7-beta_prop.
 IPR011045; N2O_reductase_N.
 IPR015943; WD40/YVTN_repeat-like_dom. 

Pfam

 PF10282; Lactonase 

SMART

  

PROSITE

  

PRINTS