UniProt Accession

 MPG1_YEAST; P41940; D6VRU1 

Genbank Protein ID

 U19608; U24437; Z74103; BK006938 

Genbank Nucleotide ID

 AAC49289.1; AAA69677.1; CAA98617.1; DAA11801.1 

Protein Name

 Mannose-1-phosphate guanyltransferase 

Protein Synonyms/Alias

 ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase 

Gene Name

 PSA1 

Gene Synonyms/Alias

 MPG1; SRB1; VIG9; YDL055C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
98	KLAEDVLKKDNSPFF	acetylation	[1]
125	KELADFHKAHGGKGT	acetylation	[1]
130	FHKAHGGKGTIVATK	ubiquitination	[2]
137	KGTIVATKVDEPSKY	acetylation	[1]
137	KGTIVATKVDEPSKY	ubiquitination	[2]
143	TKVDEPSKYGVIVHD	acetylation	[1]
143	TKVDEPSKYGVIVHD	ubiquitination	[2]
196	MKPTSIEKETFPILV	ubiquitination	[2]
239	LYLNSLAKRQPKKLA	ubiquitination	[2]
244	LAKRQPKKLATGANI	ubiquitination	[2, 3]
268	AKISSTAKIGPDVVI	acetylation	[1]
268	AKISSTAKIGPDVVI	ubiquitination	[2]
299	VLCNSTIKNHSLVKS	acetylation	[1]
299	VLCNSTIKNHSLVKS	methylation	[4]
299	VLCNSTIKNHSLVKS	ubiquitination	[2]
305	IKNHSLVKSTIVGWN	ubiquitination	[2]
348	GGKVLPHKSISDNVP	acetylation	[1]
348	GGKVLPHKSISDNVP	ubiquitination	[2, 3]
356	SISDNVPKEAIIM**	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [4] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074] 

Functional Description

 Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint. 

Sequence Annotation

 MOD_RES 153 153 Phosphothreonine.  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IDA:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0000032; P:cell wall mannoprotein biosynthetic process; IMP:SGD.
 GO:0009298; P:GDP-mannose biosynthetic process; IDA:SGD.
 GO:0006486; P:protein glycosylation; IMP:SGD. 

Interpro

 IPR001451; Hexapep_transf.
 IPR018357; Hexapep_transf_CS.
 IPR005835; NTP_transferase. 

Pfam

 PF00132; Hexapep
 PF00483; NTP_transferase 

SMART

  

PROSITE

 PS00101; HEXAPEP_TRANSFERASES 

PRINTS