| Tag | Content |
|---|
| CPLM ID | CPLM-007311 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation of fatty acids protein 3 |
Protein Synonyms/Alias | 3-keto acyl-CoA synthase ELO3; Protein SRE1; Protein SUR4; Very-long-chain 3-oxoacyl-CoA synthase 3; v-SNARE bypass mutant gene 1 protein |
Gene Name | SUR4 |
Gene Synonyms/Alias | APA1; ELO3; SRE1; VBM1; YLR372W; L8039.2 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 317 | GGKKTVKKESEVSGS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Affects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Is essential for the conversion of 24-carbon fatty acids to 26 carbon species. |
Sequence Annotation | |
Keyword | Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 345 AA |
Protein Sequence | MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF EYFSGYPAEQ 60
FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS PLKFKLLFEI HNLFLTSISL 120
VLWLLMLEQL VPMVYHNGLF WSICSKEAFA PKLVTLYYLN YLTKFVELID TVFLVLRRKK 180
LLFLHTYHHG ATALLCYTQL IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV 240
TRFQIIQFLI DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI 300
SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA 345 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:SGD. GO:0016021; C:integral to membrane; ISM:SGD. GO:0009922; F:fatty acid elongase activity; IMP:SGD. GO:0030497; P:fatty acid elongation; IMP:SGD. GO:0006892; P:post-Golgi vesicle-mediated transport; IGI:SGD. GO:0030148; P:sphingolipid biosynthetic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |