UniProt Accession

 SSPA_ECOLI; P0ACA3; P05838; Q2M8Y4 

Genbank Protein ID

 X05088; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA28740.1; AAA58031.1; AAC76261.1; BAE77272.1 

Protein Name

 Stringent starvation protein A 

Protein Synonyms/Alias

  

Gene Name

 sspA 

Gene Synonyms/Alias

 pog; ssp; b3229; JW3198 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
43	FEIEHVEKDNPPQDL	acetylation	[1]
108	LYMHRIEKDWYTLMN	acetylation	[1]
130	SEADAARKQLREELL	acetylation	[1]
181	EFSGPGAKELKGYMT	acetylation	[1, 2]
184	GPGAKELKGYMTRVF	acetylation	[1, 2]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme. It is synthesized predominantly when cells are exposed to amino acid starvation, at which time it accounts for over 50% of the total protein synthesized. It is involved in the transition from P1 early to P1 late gene expression. Rnk and SspA can functionally replace P.aeruginosa alginate regulatory gene algR2. 

Sequence Annotation

 DOMAIN 9 87 GST N-terminal.
 DOMAIN 92 209 GST C-terminal.  

Keyword

 Complete proteome; Direct protein sequencing; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS