CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041014
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 cGMP-dependent 3',5'-cyclic phosphodiesterase 
Protein Synonyms/Alias
  
Gene Name
 Pde2a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
773AHHLRIFKDLQKMAEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 935 AA 
Protein Sequence
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL SLGAVIDIAG 60
LRQAAKDALS AVLPKVETVY TYLVDGESRL VCEDPPHELP QEGKIREAVI SRKRLSCDGL 120
GPSDLLGKPL ARLVAPLAPD TQVLVIPLLD KETGTVAAVI LVHCGQLSDS EEQSLQVVEK 180
HALVALQRVQ ALQQRRPEAV QNTSADPSED QKDEKGYTAH DRKILQLCGE LYDLDATSLQ 240
LKVLRYLQQE TQATHCCLLL VSEDNLQLSC KVIGEKVLGE EVSFPLTMGR LGQVVEDKQC 300
IQLKDLTSDD VQQLQNMLGC ELRAMLCVPV ISRATDQVVA LACAFNKLGG DFFTDEDERA 360
IQHCFHYTGT VLTSTLAFQK EQKLKCECQA LLQVAKNLFT HLDDVSVLLQ EIITEARNLS 420
NAEICSVFLL DQNELVAKVF DGGVVDDESY EIRIPADQGI AGHVATTGQI LNIPDAYAHP 480
LFYRGVDDST GFRTRNILCF PIKNENQEVI GVAELVNKIN GPWFSKFDED LATAFSIYCG 540
ISIAHSLLYK KVNEAQYRSH LANEMMMYHM KVSDDEYTKL LHDGIQPVAA IDSNFANFTY 600
TPRSLPEDDT SMAILSMLQD MNFINNYKID CPTLARFCLM VKKGYRDPPY HNWMHAFSVS 660
HFCYLLYKNL ELSNYLEDIE IFALFISCMC HDLDHRGTNN SFQVASKSVL AALYSSEGSV 720
MERHHFAQAI AILNTHGCNI FDHFSRKDYQ RMLDLMRDII LATDLAHHLR IFKDLQKMAE 780
VGYDRNNKQH HRLLLCLLMT SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM 840
EMMDREKAYI PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR 900
GLPSNNSLDF LDEEYEVPDL DVTRAPVNGC CSLEG 935 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030552; F:cAMP binding; IEA:Compara.
 GO:0030553; F:cGMP binding; IEA:Compara.
 GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006198; P:cAMP catabolic process; IEA:Compara.
 GO:0019933; P:cAMP-mediated signaling; IEA:Compara.
 GO:0071321; P:cellular response to cGMP; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Compara.
 GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0046069; P:cGMP catabolic process; IEA:Compara.
 GO:0019934; P:cGMP-mediated signaling; IEA:Compara.
 GO:0030224; P:monocyte differentiation; IEA:Compara.
 GO:0033159; P:negative regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043116; P:negative regulation of vascular permeability; IEA:Compara.
 GO:0043117; P:positive regulation of vascular permeability; IEA:Compara. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.