CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin-like peptide INSL6 
Protein Synonyms/Alias
 cDNA FLJ60845, highly similar to Telomere-associated protein RIF1 
Gene Name
 RIF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43RMTGEEGKEVITEIEubiquitination[1]
109SKLNDTIKNSDKNVRubiquitination[1]
125RALWVISKQTFPSEVubiquitination[2]
198LVVHSAQKVHLRGATubiquitination[1, 2, 3]
284PDILCSAKRLKLLMQubiquitination[1, 3, 4]
287LCSAKRLKLLMQPLSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE KKLPRLYKVL 60
KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL LSKLNDTIKN SDKNVRTRAL 120
WVISKQTFPS EVVGKMVSSI IDSLEILFNK GETHSAVVDF EALNVIVRLI EQAPIQMGEE 180
AVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IASITEQLMT TTLHRSGSFI 240
NSLLQLEELG FRSGAPMIKK IAFIAWKSLI DNFALNPDIL CSAKRLKLLM QPLSSIHVRT 300
ETLALTKLEV WWYLLMRLGP HLPANFEQVL PPRTEPRELP E 341 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR022031; Rif1_N. 
Pfam
 PF12231; Rif1_N 
SMART
  
PROSITE
  
PRINTS