CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009970
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BH3-interacting domain death agonist 
Protein Synonyms/Alias
 p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID 
Gene Name
 Bid 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
123GSLSEEDKRNCLAKAubiquitination[1]
129DKRNCLAKALDEVKTubiquitination[1]
135AKALDEVKTAFPRDMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c. 
Sequence Annotation
 MOTIF 87 100 BH3.
 MOD_RES 78 78 Phosphoserine (By similarity).  
Keyword
 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 195 AA 
Protein Sequence
MDSEVSNGSG LGAEHITDLL VFGFLQSSGC TRQELEVLGR ELPVQAYWEA DLEDELQTDG 60
SQASRSFNQG RIEPDSESQE EIIHNIARHL AQIGDEMDHN IQPTLVRQLA AQFMNGSLSE 120
EDKRNCLAKA LDEVKTAFPR DMENDKAMLI MTMLLAKKVA SHAPSLLRDV FHTTVNFINQ 180
NLFSYVRNLV RNEMD 195 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0032592; C:integral to mitochondrial membrane; IDA:BHF-UCL.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
 GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0090150; P:establishment of protein localization to membrane; IEA:Compara.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:MGI.
 GO:0034349; P:glial cell apoptotic process; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IGI:BHF-UCL.
 GO:0051260; P:protein homooligomerization; IDA:BHF-UCL.
 GO:0006626; P:protein targeting to mitochondrion; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IGI:MGI.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:MGI.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara. 
Interpro
 IPR020728; Bcl2_BH3_motif_CS.
 IPR010479; BID. 
Pfam
 PF06393; BID 
SMART
  
PROSITE
 PS01259; BH3 
PRINTS