UniProt Accession

 RAB35_MOUSE; Q6PHN9 

Genbank Protein ID

 BC056466 

Genbank Nucleotide ID

 AAH56466.1 

Protein Name

 Ras-related protein Rab-35 

Protein Synonyms/Alias

  

Gene Name

 Rab35 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	AKKDNLAKQQQQQQN	ubiquitination	[1]
189	QQQNDVVKLTKNSKR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (By similarity). 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 120 123 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 LIPID 200 200 S-geranylgeranyl cysteine (By
 LIPID 201 201 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Coated pit; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0031253; C:cell projection membrane; IEA:Compara.
 GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Compara.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0045171; C:intercellular bridge; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0000910; P:cytokinesis; IEA:Compara.
 GO:0016197; P:endosomal transport; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.