| Tag | Content |
|---|
| CPLM ID | CPLM-021421 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein bicaudal C homolog 1 |
Protein Synonyms/Alias | Bic-C |
Gene Name | BICC1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 398 | PSKSVIVKSVERNAL | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. |
Sequence Annotation | DOMAIN 132 199 KH 1.
DOMAIN 284 348 KH 2.
DOMAIN 873 936 SAM.
MOD_RES 398 398 N6-acetyllysine.
MOD_RES 576 576 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Developmental protein; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 974 AA |
Protein Sequence | MAAQGEPGYL AAQSDPGSNS ERSTDSPVPG SEDDLVAGAT LHSPEWSEER FRVDRKKLEA 60
MLQAAAEGKG RSGEDFFQKI MEETNTQIAW PSKLKIGAKS KKDPHIKVSG KKEDVKEAKE 120
MIMSVLDTKS NRVTLKMDVS HTEHSHVIGK GGNNIKKVME ETGCHIHFPD SNRNNQAEKS 180
NQVSIAGQPA GVESARVRIR ELLPLVLMFE LPIAGILQPV PDPNSPSIQH ISQTYNISVS 240
FKQRSRMYGA TVIVRGSQNN TSAVKEGTAM LLEHLAGSLA SAIPVSTQLD IAAQHHLFMM 300
GRNGSNIKHI MQRTGAQIHF PDPSNPQKKS TVYLQGTIES VCLARQYLMG CLPLVLMFDM 360
KEEIEVDPQF IAQLMEQLDV FISIKPKPKQ PSKSVIVKSV ERNALNMYEA RKCLLGLESS 420
GVTIATSPSP ASCPAGLACP SLDILASAGL GLTGLGLLGP TTLSLNTSTT PNSLLNALNS 480
SVSPLQSPSS GTPSPTLWAP PLANTSSATG FSAIPHLMIP STAQATLTNI LLSGVPTYGH 540
TAPSPPPGLT PVDVHINSMQ TEGKKISAAL NGHAQSPDIK YGAISTSSLG EKVLSANHGD 600
PSIQTSGSEQ TSPKSSPTEG CNDAFVEVGM PRSPSHSGNA GDLKQMMCPS KVSCAKRQTV 660
ELLQGTKNSH LHSTDRLLSD PELSATESPL ADKKAPGSER AAERAAAAQQ NSERAHLAPR 720
SSYVNMQAFD YEQKKLLATK AMLKKPVVTE VRTPTNTWSG LGFSKSMPAE TIKELRRANH 780
VSYKPTMTTT YEGSSMSLSR SNSREHLGGG SESDNWRDRN GIGPGSHSEF AASIGSPKRK 840
QNKSTEHYLS SSNYMDCISS LTGSNGCNLN SSFKGSDLPE LFSKLGLGKY TDVFQQQEID 900
LQTFLTLTDQ DLKELGITTF GARRKMLLAI SELNKNRRKL FESPNARTSF LEGGASGRLP 960
RQYHSDIASV SGRW 974 |
Gene Ontology | GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |