UniProt Accession

 ALDOC_MOUSE; P05063; Q64011; Q8CA91; Q99K96; Q9DBA4; Q9JK32 

Genbank Protein ID

 S72537; AK005077; AK039267; BC004802; BC008184; X03796; AJ132391 

Genbank Nucleotide ID

 AAB32064.1; BAB23801.1; BAC30300.1; AAH04802.1; AAH08184.1; CAA27422.1; CAB77178.1 

Protein Name

 Fructose-bisphosphate aldolase C 

Protein Synonyms/Alias

 Aldolase 3; Brain-type aldolase; Scrapie-responsive protein 2; Zebrin II 

Gene Name

 Aldoc 

Gene Synonyms/Alias

 Aldo3; Scrg2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	ALSAEQKKELSDIAL	ubiquitination	[1]
28	LRIVTPGKGILAADE	ubiquitination	[1]
42	ESVGSMAKRLSQIGV	ubiquitination	[1]
71	FSADDRVKKCIGGVI	ubiquitination	[1]
101	FVRTIQDKGILVGIK	ubiquitination	[1]
108	KGILVGIKVDKGVVP	ubiquitination	[1]
111	LVGIKVDKGVVPLAG	ubiquitination	[1]
153	AKWRCVLKISDRTPS	ubiquitination	[1]
230	YLEGTLLKPNMVTPG	ubiquitination	[1]
330	AATEEFIKRAEMNGL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 ACT_SITE 188 188 Proton acceptor (By similarity).
 ACT_SITE 230 230 Schiff-base intermediate with
 BINDING 56 56 Substrate.
 BINDING 147 147 Substrate.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 111 111 N6-acetyllysine (By similarity).
 MOD_RES 119 119 Phosphothreonine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Phosphoprotein; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004332; F:fructose-bisphosphate aldolase activity; ISS:UniProtKB.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; ISS:UniProtKB.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0051290; P:protein heterotetramerization; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara. 

Interpro

 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 

Pfam

 PF00274; Glycolytic 

SMART

  

PROSITE

 PS00158; ALDOLASE_CLASS_I 

PRINTS