UniProt Accession

 RASF2_HUMAN; P50749; A6NIX9; A8K5Z3; Q17S06; Q53HD0; Q6AHZ2 

Genbank Protein ID

 AY154470; AY154472; D79990; AK291458; AK222650; CR627436; AL133354; CH471133; BC117118; BC117120 

Genbank Nucleotide ID

 AAN59975.1; AAN59977.1; BAA11485.2; BAF84147.1; BAD96370.1; CAH10522.1; CAC34362.1; EAX10445.1; AAI17119.1; AAI17121.1 

Protein Name

 Ras association domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 RASSF2 

Gene Synonyms/Alias

 KIAA0168 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
206	MTTPQVLKLLLNKFK	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. 

Sequence Annotation

 DOMAIN 176 264 Ras-associating.
 DOMAIN 272 319 SARAH.  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR000159; Ras-assoc.
 IPR011524; SARAH_dom. 

Pfam

 PF00788; RA 

SMART

 SM00314; RA 

PROSITE

 PS50200; RA
 PS50951; SARAH 

PRINTS