CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034658
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytoplasmic dynein 2 heavy chain 1 
Protein Synonyms/Alias
  
Gene Name
 Dync2h1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
398IIAPAEQKIAGKLKNacetylation[1]
1245VEKASDLKDLNSRAQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4303 AA 
Protein Sequence
MAGSLSDVRK LFLFTTTQNY FGLRPELWDQ TPLSNCPEVN NFLDDGNQML LRVQRSDAGL 60
AFSNTIDFDD TKDKVLVFFK LRPEVITDGN LHTNILVSSM LESPINSLYQ AVRQVFAPML 120
LKDQEWSRNF DPKLQNLLSE LEAGLGVVLR KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI 180
EQAHRGSKQI SKERASYFKE LFETIAREFY NLDSLSLLEV VDLVETTRDV VDDVWRQTEH 240
DHYPESRMLH LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH 300
LTGQVWQRYV PHPWKSEKYF PETLDRLGKR LEEVLAIRTI HEKLLYFLPA SEERIVCLSR 360
VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 420
FLKYKELVKR PTISKELMLE RETLLARLGD SAKDFRLDFE NRCRGIPGDA SGPLSGKNLS 480
EVVNNIVWVR QLELKVDDTI KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR 540
EVQSGLSDSR SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 600
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 660
SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHTTFC EKVVILMNID LLRQQQRWKD 720
GLQELRTGLA SVAAQGFQPS DMRAWRQHWN HQLYKALEHQ YQMGLEALNE NLPEINVDLT 780
YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSVMID RNASGFLTIY 840
SKAEDLFRRL SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP 900
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT EAMKVLTVIP 960
QSVEEIGDTN LQYSNLQDRR PEILPLFQEA EDKNRLLRTG RGGVETVSNL RAKWDKFELM 1020
MESHQLMIKD QVKPFHNFNI AQCVSMLYEN DSFTWSILLN EGELIMCLGR TGAFEKFAVS 1080
ILFFTLCMLL LEAKRGCWID WNHHVGTENP KFSGRAAVPP ALEVCCELQE LFNCFAPGLQ 1140
IEVMKGNVKS RLQIYYQELD KFKARWDQLK PGDDIIETGQ QNTMDQKKII IPILKYVRGE 1200
HLSPDHWLDL FRLLGLPRGT SLEKLLFGDL LRVADTIVEK ASDLKDLNSR AQGEVTIREA 1260
LRELDLWGVG AVFSLIDYED SQNRTIKLIK DWKDIVNQVG DNRCLLQSLK DSPYYKGFED 1320
KVSIWERKLA QLDEYLQNLN HIQRKWVYLE PIFGRGALPK EQTRFNKVDE DFRSIMMDIR 1380
KDSRVTTLTT HAGIRNTLLT ILDQLQRCQK SLNEFLEEKR SAFPRFYFIG DDDLLEILGQ 1440
STNPSVIQSH LKKLFAGRNQ NFSTNSLNCL IAMEGIWGQI LEQRLKIIFS IHFQAWLNDL 1500
ALEMKQTLKQ LLKECVTAGR SSQGAIDPSL FPSQILCLAE QIKFTEDVED AIRDHSLHQI 1560
EAQLAAKLER YTSVDTSSED PGNSESGILE LKLKALILDI IHNIDIVKQL NQAQVHTTDD 1620
WAWKKQVRFY MKSDHTCYVQ MVDSELQYTY EYQGNAPKLV YTPLTDKCYL TLTQAMKMGL 1680
GGNPYGPAGT GKTESVKALG GLLGRQVLVF NCDEGIDVKS MGRIFVGLVK CGAWGCFDEF 1740
NRLEEAVLSA VSMQIQTIQD ALKNHRSVCE LLGKEVEINA NSGIFITMNP AGKGYGGRQK 1800
LPDNLKQLFR PVAMSRPDND LIAEVILYSE GFKDAKELGR KLVAIFNLSR ELLTPQQHYD 1860
WGLRALKTVL RGSGNLLRQL KKSGTKQDVN ENHIVVQALR LNTMSKFTFA DCTRFDALIK 1920
DVFPGIDFKE VEYNELSSAL KQVFEEANYE VIPNQMKKAL ELYEQLRQRT GVVIVGPSGA 1980
GKSTLWRMLR AALCKIGKVV KQYTMNPKAM PRHQLLGHID MDTREWSDGV LTNSARQVVR 2040
EPQDVSSWII CDGDIDPEWI ESLNSVLDDN RLLTMPSGER IQFGPNVNFV FETHDLSCAS 2100
PATISRMGMI FLSDEETDLN SLIKSWLRNQ PVEYRSNLEN WIGDYFSKAL QWVLKQNDYV 2160
VETSLVGTVM NGLSHLHGCK YHDQFIINLI RGLGGNLNMK SRLEFTKEVF NWARETPPDS 2220
HRPMDTYFDC DRGQLASYVL KKPESLTADD FSSGHSLPVI QTPDMQRGLD YFKPWLSSET 2280
KQPFILVGPE GCGKGMLLRY AFSQLRSTEI ATIHCSAQTT SRHLLQKLSQ TCMVISTNTG 2340
RVYRPKDCER LVLYLKDINL PKLDKWGTST LVAFLQQVLT YQGFYDENLE WVGLENIQIV 2400
ASMSAGGRLG RHKLTTRFTS IVRLCAVDYP EREQLQTIYG AYLEAVLHKN LKNHSIWGSS 2460
SKIYLLAGSM VQVYEQVRAK FTVDDYSHYF FTPCILTQWV LGLFRYDLEG GSSNHPLDYV 2520
LEIVAYEARR LFRDKIVGVK ELHLFDNILT SVLQGDWGSD ILDNMADSFY VTWGAQHISG 2580
AKIAPGQPLP PHGKPLGKLS SADLKDVIKK GLIHYGRDNQ NLDILLFQEV LEYMSRIDRV 2640
LSFPGGSLLL AGRSGVGRRT VTSLVSHMHG AVLFSPKISR GYEPKQFRTD LKHVLHLAGI 2700
EAQQVVLLLE DYQFVHPTFL EMINSLLSSG EVPGLYTLEE LEPLLLPLKD QASQDGFFGP 2760
VFNYFTYRIQ QNLHIVLIMD SANLNFIINC ESNPALHKKC QVLWMEGWSD SSMKKIPEML 2820
FSEADIEEKY EKKRKDEKKK SSVDPDFIKS FLLIHESCKA YGATPSRYMT FLRVYSAISS 2880
SKRKELLKRQ SHLQAGVSKL NEAKALVDEL NRKAGEQSIL LRIKQDEADS ALQEITVSMQ 2940
DASEQKTELE RLKHRIAEEV VKIEERKSKI DDELKEVQPL VNEAKLAVGN IRPESLSEIR 3000
SLRMPPDVIR DILEGVLRLM GIFDTSWVSM KSFLAKRGVR EDIATFDARN IPKEIRESVE 3060
ELLFKNKASF DPKNAKRAST AAAPLAAWVK ANVQYSHVLE RIQPLETEQS GLELNLKKTE 3120
DRKRKLEDLL NSVGQKVSEL KEKFQSRTSE AAKLEAEVSK AQETIKAAEV LISQLDREHR 3180
RWNAQVAEIA EELATLPKRA QLAAAFITYL SAAPEGLRKN CLEEWTKAAG LEKFDLRRFL 3240
CTESEQLIWK SEGLPSDDLS IENALVILQS RVCPFLIDPS SQATEWLKTH LKDSHLEVIN 3300
QQDSNFITAL ELAVRFGKTL IIQEMDGVEP VLYPLLRRDL VAQGPRYVVQ IGDKIIDYNE 3360
DFRLFLSTRN PNPFIPPDAA SIVTEVNFTT TRSGLRGQLL ALTIQHEKPD LEEQKTKLLQ 3420
QEEDKKIQLA RLEESLLETL ATSQGNILEN KDLIESLNQT KASSALIQDS LKESYKLQIS 3480
LDQERDAYLP LAESASKMYF IISDLSKINN MYRFSLASFL RLFQRALQNK QDSESTEQRI 3540
QCLVNSLKHM VYEYICRCLF KADQLMFALH FVRGMHPEFF QENEWDTFTG VVVGDMLRKA 3600
DSQQRIRDQL PSWIDQERSW AVATLKISLP GLYQTLCFED GTLWRTYYHH SMCEQEFPSI 3660
LAKKVSLFQQ VLVVQALRPD RLQSAMALFA CKALGLKELS PLPLNLKRLY KETLEIEPIL 3720
IIISPGADPS QELQELANAE RSSECYHQVA MGQGQADLAI QMLKECARNG DWLCLKNLHL 3780
VVSWLPVLEK ELNTLQPKES FRLWLTAEVH PNFTPILLQS SLKITYESPP GLKKNLMRTY 3840
ESWTPEQISK KDNIHRAHAL FSLAWFHAAC QERRNFIPQG WTKFYEFSLS DLRAGYHVID 3900
RLFDGSKDVQ WEFVHGLLEN SIYGGRIDNY FDLRVLQSYL KQFFNSSIID VLNQRNKKSI 3960
FPYSISLPNS CSILDYRAVI EKLPEDDKPS FFGLPANIAR SSQRMTSSQV ISQLRILGRS 4020
VTAGCKFDRE IWSNELSPVL NLWKKLNQNS NLIHQKVSPP NDRQGSPILS FIILEQFNAI 4080
RLVQSVHQSL AALSKVIRGT TLLSSEVQKL ASALLNQKCP LTWQSKWEGP EDPLQYLRGL 4140
VARTLAIQNW VEKAEKQALL ADTLDLSELF HPDTFLNALR QETARATGCS VDSLKFVASW 4200
KGRLQEAKLQ IKISGLLLEG CSFDGSRLSE NQHDSPSVSS VLPCYMGWTP QGSYGPYSPD 4260
ECISLPVYTS AERDCVVTNI DVPCGGNQDQ WIQCGAALFL KNQ 4303 
Gene Ontology
 GO:0030286; C:dynein complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0030031; P:cell projection assembly; IEA:InterPro.
 GO:0001539; P:ciliary or flagellar motility; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR026815; DYNC2H1.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS