UniProt Accession

 ARC_HUMAN; Q7LC44; Q9UJW6; Q9Y469 

Genbank Protein ID

 AF193421; AF248637; D87468; BC012321; BC075802 

Genbank Nucleotide ID

 AAF07185.1; AAG33705.1; BAA19667.1; AAH12321.1; AAH75802.1 

Protein Name

 Activity-regulated cytoskeleton-associated protein 

Protein Synonyms/Alias

 ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Arg3.1 

Gene Name

 ARC 

Gene Synonyms/Alias

 KIAA0278 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	HLLAEVSKQVERELK	ubiquitination	[1]
110	ANLERWVKREMHVWR	sumoylation	[2]
268	VKNWVEFKKEFLQYS	sumoylation	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Homeostatic synaptic scaling is regulated by protein SUMOylation.
 Craig TJ, Jaafari N, Petrovic MM, Jacobs SC, Rubin PP, Mellor JR, Henley JM.
 J Biol Chem. 2012 Jun 29;287(27):22781-8. [PMID: 22582390]
 [3] The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
 Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME.
 Cell. 2010 Mar 5;140(5):704-16. [PMID: 20211139] 

Functional Description

 Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. 

Sequence Annotation

 REGION 89 100 Binds SH3GL1 or SH3GL3 (By similarity).
 REGION 195 214 Required for binding DNM2 (By  

Keyword

 Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Developmental protein; Endocytosis; Endosome; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0007492; P:endoderm development; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IEA:Compara. 

Interpro

 IPR023263; Activity-reg_cytoskelet-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02027; ARCARG31.