| Tag | Content |
|---|
| CPLM ID | CPLM-019956 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase T |
Protein Synonyms/Alias | R-PTP-T; RPTPmam4; Receptor-type tyrosine-protein phosphatase rho; RPTP-rho; mRPTPrho |
Gene Name | Ptprt |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1369 | KVVRRLEKWQEQYDG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex. |
Sequence Annotation | DOMAIN 34 195 MAM.
DOMAIN 197 288 Ig-like C2-type.
DOMAIN 292 383 Fibronectin type-III 1.
DOMAIN 390 484 Fibronectin type-III 2.
DOMAIN 485 588 Fibronectin type-III 3.
DOMAIN 670 767 Fibronectin type-III 4.
DOMAIN 902 1156 Tyrosine-protein phosphatase 1.
DOMAIN 1188 1450 Tyrosine-protein phosphatase 2.
REGION 1097 1103 Substrate binding (By similarity).
ACT_SITE 1097 1097 Phosphocysteine intermediate (By
ACT_SITE 1391 1391 Phosphocysteine intermediate (By
BINDING 1065 1065 Substrate (By similarity).
BINDING 1141 1141 Substrate (By similarity).
CARBOHYD 82 82 N-linked (GlcNAc...) (Potential).
CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
CARBOHYD 425 425 N-linked (GlcNAc...) (Potential).
CARBOHYD 514 514 N-linked (GlcNAc...) (Potential).
CARBOHYD 551 551 N-linked (GlcNAc...) (Potential).
CARBOHYD 605 605 N-linked (GlcNAc...) (Potential).
CARBOHYD 658 658 N-linked (GlcNAc...) (Potential).
CARBOHYD 688 688 N-linked (GlcNAc...) (Potential).
DISULFID 217 271 Potential. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunoglobulin domain; Membrane; Protein phosphatase; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1454 AA |
Protein Sequence | MGSLGGLALC LLRLLLLGLQ RPPLPGAGAQ SAAGGCSFDE HYSNCGYSVA LGTNGFTWEQ 60
INTWEKPMLD PAVPTGSFMM VNSSGRASGQ KAHLLLPTLK ENDTHCIDFH YYFSSRDRSS 120
PGALNVYVKV NGGPQGNPVW NVSGVVTEGW VKAELAISTF WPHFYQVIFE SVSLKGHPGY 180
IAVDEVRVLA HPCRKAPHFL RLQNVEVNVG QNATFQCIAG GKWSQHDKLW LQQWNGRDTA 240
LMVTRVVNHR RFSATVSVAD TSQRSISKYR CVIRSDGGSG VSNYAELIVK EPPTPIAPPE 300
LLAVGATYLW IKPNANSIIG DGPIILKEVE YRTTTGTWAE THIVDSPNYK LWHLDPDVEY 360
EIRVLLTRPG EGGTGPPGPP LTTRTKCADP VHGPQNVEIV DIRARQLTLQ WEPFGYAVTR 420
CHSYNLTVQY QYVFNQQQYE AEEVIQTSSH YTLRGLRPFM TIRLRLLLSN PEGRMESEEL 480
VVQTEEDVPG AVPLESIQGG PFEEKIYIQW KPPNETNGVI TLYEINYKAV GSLDPSADLS 540
SQRGKVFKLR NETHHLFVGL YPGTTYSFTI KASTAKGFGP PVTTRIATKI SAPSMPEYDA 600
DTPLNETDTT ITVMLKPAQS RGAPVSVYQL VVKEERLQKS RRAADIIECF SVPVSYRNAS 660
NLDSLHYFAA ELKPSNLPVT QPFTVGDNKT YNGYWNPPLS PLKSYSIYFQ ALSKANGETK 720
INCVRLATKG ASTQNSNTVE PEKQVDNTVK MAGVIAGLLM FIIILLGVML TIKRRRNAYS 780
YSYYLSQRKL AKKQKETQSG AQREMGPVAS TDKPTAKLGT NRNDEGFSSS SQDVNGFTDG 840
SRGELSQPTL TIQTHPYRTC DPVEMSYPRD QFQPAIRVAD LLQHITQMKR GQGYGFKEEY 900
EALPEGQTAS WDTAKEDENR NKNRYGNIIS YDHSRVRLLV LDGDPHSDYI NANYIDGYHR 960
PRHYIATQGP MQETVKDFWR MIWQENSASI VMVTNLVEVG RVKCVRYWPD DTEVYGDIKV 1020
TLIETEPLAE YVIRTFTVQK KGYHEIRELR LFHFTSWPDH GVPCYATGLL GFVRQVKFLN 1080
PPEAGPIVVH CSAGAGRTGC FIAIDTMLDM AENEGVVDIF NCVRELRAQR VNLVQTEEQY 1140
VFVHDAILEA CLCGNTAIPV CEFRSLYYNI SRLDPQTNSS QIKDEFQTLN IVTPRVRPED 1200
CSIGLLPRNH DKNRSMDVLP LDRCLPFLIS VDGESSNYIN AALMDSHKQP AAFVVTQHPL 1260
PNTVADFWRL VFDYNCSSVV MLNEMDTAQL CMQYWPEKTS GCYGPIQVEF VSADIDEDII 1320
HRIFRICNMA RPQDGYRIVQ HLQYIGWPAY RDTPPSKRSL LKVVRRLEKW QEQYDGREGR 1380
TVVHCLNGGG RSGTFCAICS VCEMIQQQNI IDVFHIVKTL RNNKSNMVET LEQYKFVYEV 1440
ALEYLSSF 1448 |
Gene Ontology | GO:0009986; C:cell surface; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0051393; F:alpha-actinin binding; IDA:MGI. GO:0045294; F:alpha-catenin binding; IDA:MGI. GO:0008013; F:beta-catenin binding; IDA:MGI. GO:0004725; F:protein tyrosine phosphatase activity; IMP:MGI. GO:0016790; F:thiolester hydrolase activity; IDA:MGI. GO:0007156; P:homophilic cell adhesion; IEA:Compara. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |