Tag | Content |
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CPLM ID | CPLM-023818 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transformation/transcription domain-associated protein |
Protein Synonyms/Alias | 350/400 kDa PCAF-associated factor; PAF350/400; STAF40; Tra1 homolog |
Gene Name | TRRAP |
Gene Synonyms/Alias | PAF400 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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1751 | PNFGDELKAKVLQHI | ubiquitination | [1] | 1796 | ITSVFITKVLDPEKQ | ubiquitination | [1] | 2004 | KWELQRIKDQQPDSD | ubiquitination | [1] | 2029 | NSVSSSIKRGLSVDS | ubiquitination | [1] | 3569 | LSLVEIYKQRCAKKG | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. |
Sequence Annotation | DOMAIN 2704 3275 FAT. DOMAIN 3528 3826 PI3K/PI4K. DOMAIN 3827 3859 FATC. REGION 2010 2388 Interaction with TP53. MOTIF 2047 2062 Bipartite nuclear localization signal MOD_RES 2051 2051 Phosphoserine. MOD_RES 2077 2077 Phosphoserine. MOD_RES 3078 3078 N6-acetyllysine. |
Keyword | Acetylation; Activator; Alternative splicing; Chromatin regulator; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3859 AA |
Protein Sequence | MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST 60 FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI PTNEHLRPHT KNVLSVMFRF 120 LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQVIP 180 ENTVPPPEMV GMITTIAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK 240 LNIHNVVAEF VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE 300 LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL 360 IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC 420 KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAV 480 EAALPGVPTA PAAPGPAPSP APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT 540 FQVTDCRSLV KTLVCGVKTI TWGITSCKAP GEAQFIPNKQ LQPKETQIYI KLVKYAMQAL 600 DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI FQTTVPYMVE 660 RISKNYALQI VANSFLANPT TSALFATILV EYLLDRLPEM GSNVELSNLY LKLFKLVFGS 720 VSLFAAENEQ MLKPHLHKIV NSSMELAQTA KEPYNYFLLL RALFRSIGGG SHDLLYQEFL 780 PLLPNLLQGL NMLQSGLHKQ HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT 840 LVSQGLRTLE LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG 900 SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL KSANTEPYYR 960 RQAWEVIKCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN VIISHRYKAQ DTPARKTFEQ 1020 ALTGAFMSAV IKDLRPSALP FVASLIRHYT MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE 1080 ENGSKGMDPL VLIDAIAICM AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY 1140 IVERLCACCY EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN 1200 GAVAMAKTTL EQLLMRCATP LKDEERAEEI VAAQEKSFHH VTHDLVREVT SPNSTVRKQA 1260 MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ PANAQIGLME GNTFCTTLQP 1320 RLFTMDLNVV EHKVFYTELL NLCEAEDSAL TKLPCYKSLP SLVPLRIAAL NALAACNYLP 1380 QSREKIIAAL FKALNSTNSE LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL 1440 TLNVVNRLTS VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NEMKICSAII 1500 NLFHLIPAAP QTLVKPLLEV VMKTERAMLI EAGSPFREPL IKFLTRHPSQ TVELFMMEAT 1560 LNDPQWSRMF MSFLKHKDAR PLRDVLAANP NRFITLLLPG GAQTAVRPGS PSTSTMRLDL 1620 QFQAIKIISI IVKNDDSWLA SQHSLVSQLR RVWVSENFQE RHRKENMAAT NWKEPKLLAY 1680 CLLNYCKRNY GDIELLFQLL RAFTGRFLCN MTFLKEYMEE EIPKNYSIAQ KRALFFRFVD 1740 FNDPNFGDEL KAKVLQHILN PAFLYSFEKG EGEQLLGPPN PEGDNPESIT SVFITKVLDP 1800 EKQADMLDSL RIYLLQYATL LVEHAPHHIH DNNKNRNSKL RRLMTFAWPC LLSKACVDPA 1860 CKYSGHLLLA HIIAKFAIHK KIVLQVFHSL LKAHAMEARA IVRQAMAILT PAVPARMEDG 1920 HQMLTHWTRK IIVEEGHTVP QLVHILHLIV QHFKVYYPVR HHLVQHMVSA MQRLGFTPSV 1980 TIEQRRLAVD LSEVVIKWEL QRIKDQQPDS DMDPNSSGEG VNSVSSSIKR GLSVDSAQEV 2040 KRFRTATGAI SAVFGRSQSL PGADSLLAKP IDKQHTDTVV NFLIRVACQV NDNTNTAGSP 2100 GEVLSRRCVN LLKTALRPDM WPKSELKLQW FDKLLMTVEQ PNQVNYGNIC TGLEVLSFLL 2160 TVLQSPAILS SFKPLQRGIA ACMTCGNTKV LRAVHSLLSR LMSIFPTEPS TSSVASKYEE 2220 LECLYAAVGK VIYEGLTNYE KATNANPSQL FGTLMILKSA CSNNPSYIDR LISVFMRSLQ 2280 KMVREHLNPQ AASGSTEATS GTSELVMLSL ELVKTRLAVM SMEMRKNFIQ AILTSLIEKS 2340 PDAKILRAVV KIVEEWVKNN SPMAANQTPT LREKSILLVK MMTYIEKRFP EDLELNAQFL 2400 DLVNYVYRDE TLSGSELTAK LEPAFLSGLR CAQPLIRAKF FEVFDNSMKR RVYERLLYVT 2460 CSQNWEAMGN HFWIKQCIEL LLAVCEKSTP IGTSCQGAML PSITNVINLA DSHDRAAFAM 2520 VTHVKQEPRE RENSESKEED VEIDIELAPG DQTSTPKTKE LSEKDIGNQL HMLTNRHDKF 2580 LDTLREVKTG ALLSAFVQLC HISTTLAEKT WVQLFPRLWK ILSDRQQHAL AGEISPFLCS 2640 GSHQVQRDCQ PSALNCFVEA MSQCVPPIPI RPCVLKYLGK THNLWFRSTL MLEHQAFEKG 2700 LSLQIKPKQT TEFYEQESIT PPQQEILDSL AELYSLLQEE DMWAGLWQKR CKYSETATAI 2760 AYEQHGFFEQ AQESYEKAMD KAKKEHERSN ASPAIFPEYQ LWEDHWIRCS KELNQWEALT 2820 EYGQSKGHIN PYLVLECAWR VSNWTAMKEA LVQVEVSCPK EMAWKVNMYR GYLAICHPEE 2880 QQLSFIERLV EMASSLAIRE WRRLPHVVSH VHTPLLQAAQ QIIELQEAAQ INAGLQPTNL 2940 GRNNSLHDMK TVVKTWRNRL PIVSDDLSHW SSIFMWRQHH YQAIVTAYEN SSQHDPSSNN 3000 AMLGVHASAS AIIQYGKIAR KQGLVNVALD ILSRIHTIPT VPIVDCFQKI RQQVKCYLQL 3060 AGVMGKNECM QGLEVIESTN LKYFTKEMTA EFYALKGMFL AQINKSEEAN KAFSAAVQMH 3120 DVLVKAWAMW GDYLENIFVK ERQLHLGVSA ITCYLHACRH QNESKSRKYL AKVLWLLSFD 3180 DDKNTLADAV DKYCIGVPPI QWLAWIPQLL TCLVGSEGKL LLNLISQVGR VYPQAVYFPI 3240 RTLYLTLKIE QRERYKSDPG PIRATAPMWR CSRIMHMQRE LHPTLLSSLE GIVDQMVWFR 3300 ENWHEEVLRQ LQQGLAKCYS VAFEKSGAVS DAKITPHTLN FVKKLVSTFG VGLENVSNVS 3360 TMFSSAASES LARRAQATAQ DPVFQKLKGQ FTTDFDFSVP GSMKLHNLIS KLKKWIKILE 3420 AKTKQLPKFF LIEEKCRFLS NFSAQTAEVE IPGEFLMPKP THYYIKIARF MPRVEIVQKH 3480 NTAARRLYIR GHNGKIYPYL VMNDACLTES RREERVLQLL RLLNPCLEKR KETTKRHLFF 3540 TVPRVVAVSP QMRLVEDNPS SLSLVEIYKQ RCAKKGIEHD NPISRYYDRL ATVQARGTQA 3600 SHQVLRDILK EVQSNMVPRS MLKEWALHTF PNATDYWTFR KMFTIQLALI GFAEFVLHLN 3660 RLNPEMLQIA QDTGKLNVAY FRFDINDATG DLDANRPVPF RLTPNISEFL TTIGVSGPLT 3720 ASMIAVARCF AQPNFKVDGI LKTVLRDEII AWHKKTQEDT SSPLSAAGQP ENMDSQQLVS 3780 LVQKAVTAIM TRLHNLAQFE GGESKVNTLV AAANSLDNLC RMDPAWHPWL 3830 |
Gene Ontology | GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB. GO:0000125; C:PCAF complex; NAS:UniProtKB. GO:0030914; C:STAGA complex; IDA:UniProtKB. GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB. GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. GO:0003713; F:transcription coactivator activity; IEA:Compara. GO:0003712; F:transcription cofactor activity; IDA:UniProtKB. GO:0016578; P:histone deubiquitination; IDA:UniProtKB. GO:0043968; P:histone H2A acetylation; IDA:UniProtKB. GO:0043967; P:histone H4 acetylation; IDA:UniProtKB. GO:0007093; P:mitotic cell cycle checkpoint; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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