UniProt Accession

 GAG_HV1H2; P04591 

Genbank Protein ID

 K03455 

Genbank Nucleotide ID

 AAB50258.1 

Protein Name

 Gag polyprotein 

Protein Synonyms/Alias

 Pr55Gag; Matrix protein p17; MA; Capsid protein p24; CA; Spacer peptide p2; Nucleocapsid protein p7; NC; Spacer peptide p1; p6-gag 

Gene Name

 gag 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2 

NCBI Taxa ID

 11706 

Lysine Modification

Position	Peptide	Type	References
475	ETTTPPQKQEPIDKE	sumoylation	[1]

Reference

 [1] Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1.
 Gurer C, Berthoux L, Luban J.
 J Virol. 2005 Jan;79(2):910-7. [PMID: 15613319] 

Functional Description

 Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. 

Sequence Annotation

 ZN_FING 390 407 CCHC-type 1.
 ZN_FING 411 428 CCHC-type 2.
 MOTIF 16 22 Nuclear export signal.
 MOTIF 26 32 Nuclear localization signal.
 MOTIF 455 458 PTAP/PSAP motif.
 MOTIF 483 492 LYPX(n)L motif.
 MOD_RES 387 387 Asymmetric dimethylarginine; in
 MOD_RES 409 409 Asymmetric dimethylarginine; in
 LIPID 2 2 N-myristoyl glycine; by host (By  

Keyword

 3D-structure; AIDS; Capsid protein; Complete proteome; Host cell membrane; Host cytoplasm; Host membrane; Host nucleus; Host-virus interaction; Lipoprotein; Membrane; Metal-binding; Methylation; Myristate; Phosphoprotein; Reference proteome; Repeat; Ribosomal frameshifting; RNA-binding; Viral budding; Viral budding via the host ESCRT complexes; Viral nucleoprotein; Virion; Virus exit from host cell; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 500 AA 

Protein Sequence

Gene Ontology

 GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046788; P:egress of virus within host cell; TAS:Reactome.
 GO:0030260; P:entry into host cell; TAS:Reactome.
 GO:0075713; P:establishment of integrated proviral latency; TAS:Reactome.
 GO:0006278; P:RNA-dependent DNA replication; TAS:Reactome.
 GO:0019061; P:uncoating of virus; TAS:Reactome.
 GO:0019082; P:viral protein processing; TAS:Reactome.
 GO:0019076; P:viral release from host cell; IEA:UniProtKB-KW.
 GO:0019068; P:virion assembly; TAS:Reactome. 

Interpro

 IPR000721; Gag_p24.
 IPR014817; Gag_p6.
 IPR000071; Lentvrl_matrix_N.
 IPR012344; Matrix_N_HIV/RSV.
 IPR008916; Retrov_capsid_C.
 IPR008919; Retrov_capsid_N.
 IPR010999; Retrovr_matrix_N.
 IPR001878; Znf_CCHC. 

Pfam

 PF00540; Gag_p17
 PF00607; Gag_p24
 PF08705; Gag_p6
 PF00098; zf-CCHC 

SMART

 SM00343; ZnF_C2HC 

PROSITE

 PS50158; ZF_CCHC 

PRINTS

 PR00234; HIV1MATRIX.