| Tag | Content |
|---|
| CPLM ID | CPLM-015196 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | O-phosphoseryl-tRNA(Sec) selenium transferase |
Protein Synonyms/Alias | Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; UGA suppressor tRNA-associated protein |
Gene Name | Sepsecs |
Gene Synonyms/Alias | D5Ertd135e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | DELRTDLKAVEAKIQ | ubiquitination | [1] | | 386 | TIDGHHDKAVTQLGS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity). |
Sequence Annotation | REGION 1 44 Tetramerization.
REGION 96 106 Phosphate loop (P-loop).
BINDING 75 75 PLP.
BINDING 97 97 Substrate.
BINDING 98 98 Substrate.
BINDING 105 105 Substrate.
BINDING 271 271 tRNA variable arm (By similarity).
BINDING 313 313 Substrate.
BINDING 398 398 tRNA discriminator base (By similarity).
MOD_RES 284 284 N6-(pyridoxal phosphate)lysine. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Protein biosynthesis; Pyridoxal phosphate; Reference proteome; RNA-binding; Selenium; Transferase; tRNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MNPESFAAGE RRVSPAYVRQ GCEARRAHEH LIRLLLEQGK CPEDGWDEST LELFLHELAV 60
MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS 120
LVLNVIKLAG VHSVASCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMV 180
TAGFEPVVIE NVLEGDELRT DLKAVEAKIQ ELGPEHILCL HSTTACFAPR VPDRLEELAV 240
ICANYDIPHV VNNAYGLQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFNE 300
PFIQDISKMY PGRASASPSL DVLITLLSLG CSGYRKLLKE RKEMFVYLST QLKKLAEAHN 360
ERLLQTPHNP ISLAMTLKTI DGHHDKAVTQ LGSMLFTRQV SGARAVPLGN VQTVSGHTFR 420
GFMSHADNYP CAYLNAAAAI GMKMQDVDLF IKRLDKCLNI VRKEQTRASV VSGADRNKAE 480
DADIEEMALK LDDVLGDVGQ GPAL 504 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HGNC. GO:0005634; C:nucleus; IDA:HGNC. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0016785; F:transferase activity, transferring selenium-containing groups; IEA:InterPro. GO:0000049; F:tRNA binding; IDA:HGNC. GO:0001514; P:selenocysteine incorporation; IDA:HGNC. GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |