UniProt Accession

 UHPA_SALTY; P27667 

Genbank Protein ID

 M89480; AE006468 

Genbank Nucleotide ID

 AAA27243.1; AAL22648.1 

Protein Name

 Transcriptional regulatory protein UhpA 

Protein Synonyms/Alias

  

Gene Name

 uhpA 

Gene Synonyms/Alias

 STM3790 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
179	HRANLLEKLGVSNDV	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Appears to be the positive activator of UhpT transcription. 

Sequence Annotation

 DOMAIN 1 116 Response regulatory.
 DOMAIN 131 196 HTH luxR-type.
 DNA_BIND 155 174 H-T-H motif (By similarity).
 MOD_RES 54 54 4-aspartylphosphate (By similarity).  

Keyword

 Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Sugar transport; Transcription; Transcription regulation; Transport; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00196; GerE
 PF00072; Response_reg 

SMART

 SM00421; HTH_LUXR
 SM00448; REC 

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2
 PS50110; RESPONSE_REGULATORY 

PRINTS

 PR00038; HTHLUXR.