CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-aminobutyric acid receptor subunit alpha-5 
Protein Synonyms/Alias
 GABA(A) receptor subunit alpha-5 
Gene Name
 GABRA5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
355GWAWDGKKALEAAKIubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
Sequence Annotation
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).
 CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).
 DISULFID 173 187 By similarity.
 CROSSLNK 355 355 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT RILDGLLDGY 60
DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF RQSWKDERLR FKGPMQRLPL 120
NNLLASKIWT PDTFFHNGKK SIAHNMTTPN KLLRLEDDGT LLYTMRLTIS AECPMQLEDF 180
PMDAHACPLK FGSYAYPNSE VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS 240
TGEYTIMTAH FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM 300
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA WDGKKALEAA 360
KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT TSVSVKPSEE KTSESKKTYN 420
SISKIDKMSR IVFPVLFGTF NLVYWATYLN REPVIKGAAS PK 462 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0032809; C:neuronal cell body membrane; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; IEA:Compara.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0008306; P:associative learning; IEA:Compara.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0090102; P:cochlea development; IEA:Compara.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
 GO:0060119; P:inner ear receptor cell development; IEA:Compara.
 GO:0060384; P:innervation; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR001390; GABAAa_rcpt.
 IPR005435; GABBAa5_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR01079; GABAARALPHA.
 PR01618; GABAARALPHA5.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.