UniProt Accession

 LEG8_HUMAN; O00214; O15215; Q5T3P5; Q5T3Q4; Q8TEV1; Q96B92; Q9BXC8; Q9H584; Q9H585; Q9UEZ6; Q9UP32; Q9UP33; Q9UP34 

Genbank Protein ID

 L78132; X91790; AF074000; AF074001; AF074002; AF193806; AF193805; AF342815; AF342816; AF468213; AL359921; AL359921; BC015818; BC016486 

Genbank Nucleotide ID

 AAB51605.1; CAA62904.1; AAD45402.1; AAD45403.1; AAD45404.1; AAF19370.1; AAF19370.1; AAK16735.1; AAK16736.1; AAL77076.1; CAI13773.1; CAI13774.1; AAH15818.1; AAH16486.2 

Protein Name

 Galectin-8 

Protein Synonyms/Alias

 Gal-8; Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1; PCTA-1 

Gene Name

 LGALS8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
193	NRGGDISKIAPRTVY	ubiquitination	[1]
254	GEVNANAKSFNVDLL	ubiquitination	[1, 2]
264	NVDLLAGKSKDIALH	ubiquitination	[1, 3]
266	DLLAGKSKDIALHLN	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. 

Sequence Annotation

 DOMAIN 19 152 Galectin 1.
 DOMAIN 187 317 Galectin 2.
 REGION 249 255 Beta-galactoside binding (By similarity).
 BINDING 69 69 Carbohydrate.
 BINDING 79 79 Carbohydrate.
 BINDING 89 89 Carbohydrate.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Lectin; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; TAS:ProtInc.
 GO:0002317; P:plasma cell differentiation; IEA:Compara.
 GO:0031295; P:T cell costimulation; IEA:Compara. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR001079; Galectin_CRD. 

Pfam

 PF00337; Gal-bind_lectin 

SMART

 SM00908; Gal-bind_lectin
 SM00276; GLECT 

PROSITE

 PS51304; GALECTIN 

PRINTS