CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology-like domain family A member 2 
Protein Synonyms/Alias
 Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C 
Gene Name
 PHLDA2 
Gene Synonyms/Alias
 BWR1C; HLDA2; IPL; TSSC3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKSPDEVLRubiquitination[1]
15LREGELEKRSDSLFQubiquitination[1, 2]
25DSLFQLWKKKRGVLTubiquitination[1, 2, 3]
57LRFHSILKVDCVERTubiquitination[3]
66DCVERTGKYVYFTIVubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). 
Sequence Annotation
 DOMAIN 7 99 PH.
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 141 141 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 151 151 Phosphothreonine.  
Keyword
 Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 152 AA 
Protein Sequence
MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC 60
VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA 120
APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP 152 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0009887; P:organ morphogenesis; IEA:Compara. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
  
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS