| Tag | Content |
|---|
| CPLM ID | CPLM-015790 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RAS guanyl-releasing protein 2 |
Protein Synonyms/Alias | Calcium and DAG-regulated guanine nucleotide exchange factor I; CalDAG-GEFI; Cdc25-like protein; hCDC25L; F25B3.3 kinase-like protein |
Gene Name | RASGRP2 |
Gene Synonyms/Alias | CDC25L; MCG7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 128 | IDSVPTYKWKRQVTQ | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. |
Sequence Annotation | DOMAIN 4 126 N-terminal Ras-GEF.
DOMAIN 154 387 Ras-GEF.
DOMAIN 426 461 EF-hand 1.
DOMAIN 455 490 EF-hand 2.
ZN_FING 498 548 Phorbol-ester/DAG-type.
MOD_RES 116 116 Phosphoserine (By similarity).
MOD_RES 117 117 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Synapse; Synaptosome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 609 AA |
Protein Sequence | MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY 60
QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID 120
IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS 180
FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF 240
NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR 300
FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL 360
LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ 420
ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM 480
VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC 540
KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV 600
EDGVFDIHL 609 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005829; C:cytosol; IDA:UniProtKB. GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. GO:0045202; C:synapse; IEA:UniProtKB-KW. GO:0005509; F:calcium ion binding; NAS:UniProtKB. GO:0019992; F:diacylglycerol binding; NAS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB. GO:0030168; P:platelet activation; TAS:Reactome. GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB. GO:0001558; P:regulation of cell growth; NAS:UniProtKB. GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |