| Tag | Content |
|---|
| CPLM ID | CPLM-007171 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine nucleotide-binding protein subunit beta 2 |
Protein Synonyms/Alias | Gbeta mimic kelch protein 2 |
Gene Name | GPB2 |
Gene Synonyms/Alias | KRH1; YAL056W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 686 | RLILSQEKPVGKTVV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth. |
Sequence Annotation | REPEAT 291 339 Kelch 1.
REPEAT 377 425 Kelch 2.
REPEAT 501 552 Kelch 3.
REPEAT 691 738 Kelch 4.
MOD_RES 24 24 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Kelch repeat; Mitochondrion; Phosphoprotein; Reference proteome; Repeat; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 880 AA |
Protein Sequence | MEISSSPWND GGYSPYERNR VAVSPFSSAL EGEERIETSR SLGDHCFEPL PYVTNYLSIF 60
ALFGKEIFGD KGNVSSRNEY LLKKYYSLKK PFVLRHNGHA LKNPDMPLQR NDILQTNFMV 120
DKFLNRTVRS VNFNNFKIIS DMQSKSGRGT KSGTNQNQSA DAIQNICLPS IPSALPYFQY 180
YRKLLTVNTK EWDILKLHSL WVPKLRKDFK DFSLYGDKNS LKPIDSHYDE DNTMKKNLFF 240
ERSPSRQTLD GKGCASKGYD ISSGNMIIPS LFSEDKLPAL TYHCSVELNG NIYIFGGLMP 300
CYSYEEDAPM LNDFFVDGIK NLPPPLLPQV INNPSMVNNP HLYVASIPSC RFSKPKMGGY 360
IPPPLLCVQG SKLTDRHIFF YGGFEIRTET RGDENGKYHL KKRLYVNNTG YILDIMSFKF 420
TKIDIIVQPS KYNAYPTMSS RFGHLQISID NPNRRASVHS SSMNEIHKMG SASMKQGSSI 480
TSGRLEKAAV LSSLPHNTVH TVIIFGGYRQ TGDDRYEAMN DLWKIEIPVI RRGKKGYCKF 540
SETANAILLT PSEKDKSDWP EERAFSAFSV HGTSLMDRSS LDMRLLNNLK NHFVLKPSYI 600
SQDRVVSPKP VFPMMVHGTH QDLFNSGSAA QESPKAGASA SSASAASFDP DMDDNLENYI 660
VNPGRKSSSI PMTAIGRQRL ILSQEKPVGK TVVLHGGSNG LNVLDDMWLM DLECETWTPI 720
ETFAKADSSE DGDEKLDSVN VGLVGHRMES IGRICVCIGG MVQEDVDQFY SENDDEPPRK 780
RKVDTLPLGG NFLNTIDLST QCWEEHKITL SKKEDDEDRQ DSENEDTNSN IVVGVGGTSL 840
QCDKSIILIG GLISRRSNVK EIYLHGTITK SIFPSVNPSA 880 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IGI:SGD. GO:0004871; F:signal transducer activity; IPI:SGD. GO:0030437; P:ascospore formation; IMP:SGD. GO:0010255; P:glucose mediated signaling pathway; IMP:SGD. GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD. GO:0046580; P:negative regulation of Ras protein signal transduction; IGI:SGD. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD. GO:0007124; P:pseudohyphal growth; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |