| Tag | Content |
|---|
| CPLM ID | CPLM-011226 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 2 |
Protein Synonyms/Alias | Enhancer of split groucho-like protein 2; ESG2 |
Gene Name | TLE2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | CEKLASEKTEMQRHY | ubiquitination | [1] | | 82 | HKQAEIVKRLSGICA | ubiquitination | [1] | | 481 | TGGKGCVKVWDVGQP | ubiquitination | [1] | | 510 | DNYIRSCKLLPDGRS | ubiquitination | [1] | | 540 | AAPTPRIKAELTSSA | ubiquitination | [1] | | 691 | RWFVSTGKDNLLNAW | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Sequence Annotation | REPEAT 455 493 WD 1.
REPEAT 501 540 WD 2.
REPEAT 545 584 WD 3.
REPEAT 587 626 WD 4.
REPEAT 669 708 WD 5.
REPEAT 710 742 WD 6.
REGION 195 256 CCN domain.
MOTIF 214 217 Nuclear localization signal (Potential).
MOD_RES 228 228 Phosphoserine; by CK2 (Potential).
MOD_RES 249 249 Phosphoserine; by CDK1 (Potential).
MOD_RES 253 253 Phosphothreonine; by CDK1 (Potential).
MOD_RES 281 281 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 743 AA |
Protein Sequence | MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 60
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 120
LIGQQLQPLS HHAPPVPLTP RPAGLVGGSA TGLLALSGAL AAQAQLAAAV KEDRAGVEAE 180
GSRVERAPSR SASPSPPESL VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD 240
EDQPSEPPSP ATTPCGKVPI CIPARRDLVD SPASLASSLG SPLPRAKELI LNDLPASTPA 300
SKSCDSSPPQ DASTPGPSSA SHLCQLAAKP APSTDSVALR SPLTLSSPFT TSFSLGSHST 360
LNGDLSVPSS YVSLHLSPQV SSSVVYGRSP VMAFESHPHL RGSSVSSSLP SIPGGKPAYS 420
FHVSADGQMQ PVPFPSDALV GAGIPRHARQ LHTLAHGEVV CAVTISGSTQ HVYTGGKGCV 480
KVWDVGQPGA KTPVAQLDCL NRDNYIRSCK LLPDGRSLIV GGEASTLSIW DLAAPTPRIK 540
AELTSSAPAC YALAVSPDAK VCFSCCSDGN IVVWDLQNQT MVRQFQGHTD GASCIDISDY 600
GTRLWTGGLD NTVRCWDLRE GRQLQQHDFS SQIFSLGHCP NQDWLAVGME SSNVEILHVR 660
KPEKYQLHLH ESCVLSLKFA SCGRWFVSTG KDNLLNAWRT PYGASIFQSK ESSSVLSCDI 720
SRNNKYIVTG SGDKKATVYE VVY 743 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003714; F:transcription corepressor activity; IDA:UniProtKB. GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0007219; P:Notch signaling pathway; TAS:Reactome. GO:0009887; P:organ morphogenesis; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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