CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 63B 
Protein Synonyms/Alias
  
Gene Name
 Tmem63b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
233HTSKMRYKEDDLVKRubiquitination[1]
258AESEKIKKHFEEAYPubiquitination[1]
295RKKAERGKLYFTNLQubiquitination[1]
304YFTNLQSKENVPAMIubiquitination[1]
338EAIEYYTKLEQRLKEubiquitination[1]
548FRWLFDKKFLAEAAIacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
  
Sequence Annotation
 MOD_RES 111 111 Phosphoserine.
 MOD_RES 114 114 Phosphoserine (By similarity).
 CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
 CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
 CARBOHYD 462 462 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MLPFLLATLG TAALNSSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS 60
ILRKVAWDYG RLALVTDADR LRRQERERVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ 120
RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG 180
DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR 240
TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN 300
LQSKENVPAM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QRLKEDYRRE KEKVNEKPLG 360
MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRASSCSE ALHISNWTVT YAPDPQNIYW 420
EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP 480
TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF 540
FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL 600
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR 660
YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT 720
IVICLCHVCF GHFKYLSAHN YKIEHTETDA VSSRSNGRPP TAGAVPKSAK YIAQVLQDSE 780
GDGDGDGAPG SSGDEPPSSS SQDEELLMPP DGLTDTDFQS CEDSLIENEI HQ 832 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR003864; DUF221.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR026957; TMEM63. 
Pfam
 PF02714; DUF221 
SMART
  
PROSITE
  
PRINTS