| Tag | Content |
|---|
| CPLM ID | CPLM-024140 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 1 |
Protein Synonyms/Alias | |
Gene Name | Mtmr1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | FAFNYKEKFPVNGWK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Lipid phosphatase that acts on phosphatidylinositol 3- phosphate and phosphatidylinositol (3,5)-bisphosphate (By similarity). |
Sequence Annotation | DOMAIN 94 165 GRAM.
DOMAIN 230 605 Myotubularin phosphatase.
REGION 355 358 Substrate binding (By similarity).
REGION 380 381 Substrate binding (By similarity).
REGION 442 448 Substrate binding (By similarity).
ACT_SITE 442 442 Phosphocysteine intermediate (By
BINDING 488 488 Substrate (By similarity).
MOD_RES 47 47 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Hydrolase; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET LDSPTGSHVE 60
WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME EAPLFPGESI KAIVKDVIYI 120
CPFMGAVSGT LTVTDFKMYF KNVERDPHFV LDVPLGVISR VEKIGAQSHG DNSCGIEIVC 180
KDMRNLRLAY KQEEQRKLGI FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY 240
KRQGLPNESW KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP 300
ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS VADTNKAKGG 360
GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID ESHWLSNVDG THWLEYIRVL 420
LAGAVRIADK IESGKTSVVI HCSDGWDRTS QLTSLAMLML DSYYRTIKGF EALIEKEWIS 480
FGHRFALRVG HGDDNHADAD RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC 540
LFGTFLCNCE QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL 600
WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS SSERGSSPTH 660
SATPVHTSV 669 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005886; C:plasma membrane; IDA:MGI. GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:MGI. GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |