CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA polymerase I-specific transcription initiation factor RRN3 
Protein Synonyms/Alias
  
Gene Name
 Rrn3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
60TVTEVLLKYKKGETNacetylation[1]
60TVTEVLLKYKKGETNsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction. 
Sequence Annotation
 REGION 498 650 Interaction with TWISTNB (By similarity).
 REGION 555 650 Interaction with EIF3L (By similarity).
 MOD_RES 168 168 Phosphoserine (By similarity).
 MOD_RES 170 170 Phosphoserine (By similarity).
 MOD_RES 198 198 Phosphothreonine; by MAPK9 (By
 MOD_RES 638 638 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MAAPLLHTRL SGDVTAAASA TLSASRTGLS DMLALESDFF NSPPKKTVRF GGTVTEVLLK 60
YKKGETNDLE LLKNQLSDPD IKDDQIINWL LEFRSSVMYL TKDFEQLINI ILRLPWLNRS 120
QRVVEEYLAF LGNLVSAQTV FLRPCLSMIA SHFVPPRVIV KEGGIDVSDS DDEDDNLPAI 180
FDTCHRALQI ITRYVPSTPW FLMPILVEKF PFVRKSERTL ECYVHNLLRI SLYFPTLRRE 240
ILELVIEKLL KLDVSVSRQD IEDAEEKAAQ TCGGTDTTEG LFNMDEDEDT DPEKKADQEQ 300
PNQMAHPTAE RLDVLLCLLL SYIEDVCRVH GKIDNNKTKD LYRDLISIFD KLLLPTHASC 360
HVQFFMFFLC SFKLGFAEAF LEHLWKKLQD PNNPAIIRQA AANYIGSFLA RAKFIPLITV 420
KTCLDLLVNW LHMYLTNQDS GTKAFCDVAL HGPFYSACQA VFYTVVFRHK QLLSGNLKQG 480
LQYLQSLNFE RIVLSQLNPL KICLPQVVNF FAAITNKYQL VFCYTIMERN SRQMLPVIRS 540
TAGGDSVQTC TNPLDTFFPF DPCVLKRSKK FIDPIYQIWE DGSAEELQEF KKSTKKEVVE 600
DEDDDFLKGE VPQSDTVTGL TPSSFDTHFQ SPSSSVGSPP VLYIPGQSPL LTRIYD 656 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0070063; F:RNA polymerase binding; IDA:MGI.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0007028; P:cytoplasm organization; IMP:MGI.
 GO:0048872; P:homeostasis of number of cells; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0007000; P:nucleolus organization; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:2000142; P:regulation of DNA-dependent transcription, initiation; IDA:MGI.
 GO:0042254; P:ribosome biogenesis; IMP:MGI.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; IMP:MGI. 
Interpro
 IPR007991; RNA_pol_I_trans_ini_fac_RRN3. 
Pfam
 PF05327; RRN3 
SMART
  
PROSITE
  
PRINTS