UniProt Accession

 SEPT1_HUMAN; Q8WYJ6; B4DVE6; Q658T1; Q8NEZ1; Q96EL4; Q9H285 

Genbank Protein ID

 AF085235; AY034176; AK301045; BC012161; AL833004; AF308288 

Genbank Nucleotide ID

 AAL40393.1; AAK61491.1; BAG62658.1; AAH12161.1; CAH56484.1; AAG48256.1 

Protein Name

 Septin-1 

Protein Synonyms/Alias

 LARP; Peanut-like protein 3; Serologically defined breast cancer antigen NY-BR-24 

Gene Name

 SEPT1 

Gene Synonyms/Alias

 DIFF6; PNUTL3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MDKEYVGFAA	ubiquitination	[1, 2]
22	LHRKSVKKGFDFTLM	ubiquitination	[2]
82	EIEEGGVKVKLTLVD	ubiquitination	[2]
84	EEGGVKVKLTLVDTP	ubiquitination	[2]
162	FLRAVHEKVNIIPVI	ubiquitination	[1, 2]
171	NIIPVIGKADALMPQ	ubiquitination	[1, 2]
184	PQETQALKQKIRDQL	ubiquitination	[1, 2]
220	KRQDAEMKESIPFAV	ubiquitination	[2]
278	QTHLQDLKEVTHDLL	ubiquitination	[2]
331	LPLADTEKLIREKDE	ubiquitination	[1, 2]
349	RMQEMLEKMQAQMQQ	ubiquitination	[1, 2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). 

Sequence Annotation

 NP_BIND 32 39 GTP (By similarity).
 NP_BIND 171 179 GTP (By similarity).
 BINDING 66 66 GTP (By similarity).
 BINDING 92 92 GTP; via amide nitrogen (By similarity).
 BINDING 229 229 GTP; via amide nitrogen and carbonyl
 BINDING 245 245 GTP (By similarity).
 MOD_RES 248 248 Phosphoserine; by AURKB.
 MOD_RES 307 307 Phosphoserine; by AURKB.
 MOD_RES 315 315 Phosphoserine; by AURKB.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS