UniProt Accession

 SETD7_MOUSE; Q8VHL1; Q6ZPJ6; Q80UU3; Q8C7Y6 

Genbank Protein ID

 AF448509; AK129428; AK048924; AK147422; AK147413; AK147667; AK170161; BC050190 

Genbank Nucleotide ID

 AAL56578.1; BAC98238.1; BAC33493.1; BAE27903.1; BAE27897.1; BAE28059.1; BAE41607.1; AAH50190.1 

Protein Name

 Histone-lysine N-methyltransferase SETD7 

Protein Synonyms/Alias

 Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain-containing protein 7; SET7/9 

Gene Name

 Setd7 

Gene Synonyms/Alias

 Kiaa1717; Set7; Set9 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
317	HPRFGPIKCIRTLRA	acetylation	[1]
317	HPRFGPIKCIRTLRA	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. 

Sequence Annotation

 REPEAT 36 58 MORN 1.
 REPEAT 59 81 MORN 2.
 REPEAT 106 128 MORN 3.
 DOMAIN 214 336 SET.
 REGION 226 228 S-adenosyl-L-methionine binding (By
 REGION 256 258 Substrate binding (By similarity).
 REGION 266 268 Substrate binding (By similarity).
 REGION 296 297 S-adenosyl-L-methionine binding (By
 BINDING 245 245 Substrate (By similarity).
 BINDING 317 317 Substrate (By similarity).
 BINDING 335 335 Substrate; via carbonyl oxygen (By
 BINDING 356 356 S-adenosyl-L-methionine; via carbonyl  

Keyword

 Activator; Chromatin regulator; Chromosome; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 366 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0018024; F:histone-lysine N-methyltransferase activity; ISS:UniProtKB.
 GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.
 GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017155; Hist-Lys_N-MeTrfase_SET.
 IPR003409; MORN.
 IPR001214; SET_dom. 

Pfam

 PF02493; MORN
 PF00856; SET 

SMART

 SM00317; SET 

PROSITE

 PS51577; SAM_MT43_SET7
 PS50280; SET 

PRINTS