UniProt Accession

 CSN4_RAT; Q68FS2 

Genbank Protein ID

 BC079384 

Genbank Nucleotide ID

 AAH79384.1 

Protein Name

 COP9 signalosome complex subunit 4 

Protein Synonyms/Alias

 SGN4; Signalosome subunit 4; JAB1-containing signalosome subunit 4 

Gene Name

 Cops4 

Gene Synonyms/Alias

 Csn4 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
25	SHKDLAGKYRQILEK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). 

Sequence Annotation

 DOMAIN 201 363 PCI.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 25 25 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IEA:UniProtKB-KW.
 GO:0010388; P:cullin deneddylation; IEA:Compara. 

Interpro

 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS