UniProt Accession

 UPK2_HUMAN; O00526; B0YJ92; O00457; Q53YV0 

Genbank Protein ID

 Y13645; AB078607; AY455312; EF445028; BC113900; AF000562 

Genbank Nucleotide ID

 CAA73996.1; BAB84089.1; AAR19396.1; ACA06070.1; AAI13901.1; AAB58416.1 

Protein Name

 Uroplakin-2 

Protein Synonyms/Alias

 UP2; Uroplakin II; UPII 

Gene Name

 UPK2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	YISYLVKKGTATESS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). 

Sequence Annotation

 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0016044; P:cellular membrane organization; IEA:InterPro.
 GO:0030855; P:epithelial cell differentiation; IDA:UniProtKB.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc. 

Interpro

 IPR009952; Uroplakin_II. 

Pfam

 PF07353; Uroplakin_II 

SMART

  

PROSITE

  

PRINTS