CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cat eye syndrome critical region protein 5 
Protein Synonyms/Alias
  
Gene Name
 CECR5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
69RVIPAALKAFRRLVNacetylation[1]
69RVIPAALKAFRRLVNubiquitination[2]
132LFSEYHEKRMLVSGQubiquitination[2]
177VDLERRLKTTPLPRNubiquitination[2, 3]
279RYEGLMGKPSILTYQubiquitination[2, 4]
307GWAAPIRKLYAVGDNubiquitination[2]
331LFHQYLQKATHDGAPubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MAAWGCVAAL GAARGLCWRA ARAAAGLQGR PARRCYAVGP AQSPPTFGFL LDIDGVLVRG 60
HRVIPAALKA FRRLVNSQGQ LRVPVVFVTN AGNILQHSKA QELSALLGCE VDADQVILSH 120
SPMKLFSEYH EKRMLVSGQG PVMENAQGLG FRNVVTVDEL RMAFPLLDMV DLERRLKTTP 180
LPRNDFPRIE GVLLLGEPVR WETSLQLIMD VLLSNGSPGA GLATPPYPHL PVLASNMDLL 240
WMAEAKMPRF GHGTFLLCLE TIYQKVTGKE LRYEGLMGKP SILTYQYAED LIRRQAERRG 300
WAAPIRKLYA VGDNPMSDVY GANLFHQYLQ KATHDGAPEL GAGGTRQQQP SASQSCISIL 360
VCTGVYNPRN PQSTEPVLGG GEPPFHGHRD LCFSPGLMEA SHVVNDVNEA VQLVFRKEGW 420
ALE 423 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR023214; HAD-like_dom.
 IPR006357; HAD-SF_hydro_IIA.
 IPR006353; HAD-SF_hydro_IIA_CECR5. 
Pfam
 PF13344; Hydrolase_6 
SMART
  
PROSITE
  
PRINTS