CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 9 
Protein Synonyms/Alias
  
Gene Name
 Arhgef9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
349QAAMTVRKASKQKGVacetylation[1]
352MTVRKASKQKGVNSAacetylation[1]
354VRKASKQKGVNSARSacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MRANVINEIM STERHYIKHL KDICEGYLKQ CRKRRDMFSD EQLKVIFGNI EDIYRFQMGF 60
VRDLEKQYNN DDPHLSEIGP CFLEHQDGFW IYSEYCNNHL DACMELSKLM KDSRYQHFFE 120
ACRLLQQMID IAIDGFLLTP VQKICKYPLQ LAELLKYTAQ DHSDYRYVAA ALAVMRNVTQ 180
QINERKRRLE NIDKIAQWQA SVLDWEGEDI LDRSSELIYT GEMAWIYQPY GRNQQRVFFL 240
FDHQMVLCKK DLIRRDILYY KGRIDMDKYE VIDIEDGRDD DFNVSMKNAF KLHNKETEEV 300
HLFFAKKLEE KIRWLRAFRE ERKMVQEDEK IGFEISENQK RQAAMTVRKA SKQKGVNSAR 360
SVPPSYPPPQ DPLNQGQYLV PDGIAQSQVF EFTEPKRSQS PFWQNFSRLT PFKK 414 
Gene Ontology
 GO:0005938; C:cell cortex; TAS:MGI.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS