CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030265
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Itsn2 protein 
Protein Synonyms/Alias
  
Gene Name
 Itsn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
584SGISLLHKKSSEKEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1685 AA 
Protein Sequence
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120
SMPNLSIHQP LPPVAPIATP LSSATSGTSI PPLMMPAPLV PSVSTSSLPN GTASLIQPLS 180
IPYSSSTLPH ASSYSLMMGG FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA 240
VPQPSRLKYR QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA 300
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK TQEEEPQKKL 360
PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK EKEEWERKQR ELQEQEWKKQ 420
LELEKRLEKQ RELERQREEE RRKEIERREA AKQELERQRR LEWERLRRQE LLSQKTREQE 480
DIVRLSSRKK SLHLELEAVN GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ 540
LQQELKEYQN KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL 600
DALEKETASK LSEMDSFNNQ LKCGSMDDCV LQCLLSLLSC LNNLFLLLKE LRESYNTQQL 660
ALEQLHKIKR DKLKEIERKR LEQIQKKKLE DEAARKAKQG KENLWRESIR KEEEEKQKRL 720
QEEKSQDKTQ EEERKAEAKQ SETASALVNY RALYPFEARN HDEMSFSSGD IIQVDEKTVG 780
EPGWLYGSFQ GKFGWFPCNY VEKVLSSEKA LSPKKALLPP TVSLSATSTS SQPPASVTDY 840
HNVSFSNLTV NTTWQQKSAF TRTVSPGSVS PIHGQGQAVE NLKAQALCSW TAKKENHLNF 900
SKHDVITVLE QQENWWFGEV HGGRGWFPKS YVKLIPGNEV QRGEPEALYA AVTKKPTSTA 960
YPVTSTAYPV GEDYIALYSY SSVEPGDLTF TEGEEILVTQ KDGEWWTGSI GERTGIFPSN 1020
YVRPKDQENF GNASKSGASN KKPEIAQVTS AYAASGTEQL SLAPGQLILI LKKNTSGWWQ 1080
GELQARGKKR QKGWFPASHV KLLGPSSERT MPTFHAVCQV IAMYDYMANN EDELNFSKGQ 1140
LINVMNKDDP DWWQGETNGL TGLFPSNYVK MTTDSDPSQQ WCADLQALDT MQPTERKRQG 1200
YIHELIQTEE RYMDDLQLVI EVFQKRMAES GFLTEADMAL IFVNWKELIM SNTKLLRALR 1260
VRKKTGGEKM PVQMIGDILA AELSHMQAYI RFCSCQLNGA TLLQQKTDED TDFKEFLKKL 1320
ASDPRCKGMP LSSFLLKPMQ RITRYPLLIR SILENTPQSH VDHSSLKLAL ERAEELCSQV 1380
NEGVREKENS DRLEWIQAHV QCEGLAEQLI FNSLTNCLGP RKLLHSGKLY KTKSNKELHA 1440
FLFNDFLLLT YLVRQFAAAS GHEKLFNSKS SAQFRMYKTP IFLNEVLVKL PTDPSSDEPV 1500
FHISHIDRVY TLRTDNINER TAWVQKIKGA SEQYIDTEKK KREKAYQARS QKTSGIGRLM 1560
VHVIEATELK ACKPNGKSNP YCEVSMGSQS YTTRTLQDTL NPKWNFNCQF FIKDLYQDVL 1620
CLTMFDRDQF SPDDFLGRTE VPVAKIRTEQ ESKGPTTRRL LLHEVPTGEV WVRFDLQLFE 1680
QKTLL 1685 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027029; Intersectin-2.
 IPR000108; p67phox.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00168; C2
 PF00621; RhoGEF
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00239; C2
 SM00054; EFh
 SM00027; EH
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50004; C2
 PS50010; DH_2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.