| Tag | Content |
|---|
| CPLM ID | CPLM-024727 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tripartite motif-containing protein 2 |
Protein Synonyms/Alias | E3 ubiquitin-protein ligase TRIM2 |
Gene Name | Trim2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 483 | VGTKGRNKGEFTNLQ | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance. |
Sequence Annotation | REPEAT 320 421 Filamin.
REPEAT 473 516 NHL 1.
REPEAT 520 563 NHL 2.
REPEAT 564 605 NHL 3.
REPEAT 609 652 NHL 4.
REPEAT 656 699 NHL 5.
REPEAT 700 743 NHL 6.
ZN_FING 23 64 RING-type.
ZN_FING 113 154 B box-type.
MOD_RES 440 440 Phosphoserine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MASEGASIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC 60
PVCRQTSILP EKGVAALQNN FFITNLMDVL QRTPGSNGED PSILQTVTAV AAGKPLSCPN 120
HDGNVMEFYC QSCETAMCRE CTEGEHAEHP TVPLKDVVEQ HKASLQVQLD AVNKRLPEID 180
SALQFISEII HQLTNQKASI VDDIHSTFDE LQKTLNVRKS VLLMELEVNY GLKHKVLQSQ 240
LDTLLQGQES IKSCSNFTAQ ALNHGTETEV LLVKKQMSEK LNELADQDFP LHPRENDQLD 300
FIVETEGLKK SIHNLGTILT TNAVASETVA TGEGLRQTII GQPMSVTITT KDKDGELCKT 360
GNAYLTAELS TPDGSVADGE ILDNKNGTYE FLYTVQKEGD FTLSLRLYDQ HIRGSPFKLK 420
VIRSADVSPT TEGVKRRVKS PGSGHVKQKA VKRPASMYST GKRKENPIED DLIFRVGTKG 480
RNKGEFTNLQ GVAASTSGKI LIADSNNQCV QIFSNDGQFK SRFGIRGRSP GQLQRPTGVA 540
VHPSGDIIIA DYDNKWVSIF SNDGKFKTKI GSGKLMGPKG VSVDRNGHII VVDNKACCVF 600
IFQPNGKIVT RFGSRGNGDR QFAGPHFAAV NSSNEIIITD FHNHSVKVFN QEGEFMLKFG 660
SNGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDGSG SFLSYINTSA DPLYGPQGLA 720
LTSDGHVVVA DSGNHCFKVY RYLQ 744 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |