CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032002
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch-like protein 7 
Protein Synonyms/Alias
 cDNA FLJ52310, highly similar to Kelch-like protein 7 
Gene Name
 KLHL7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15VRFPLISKNFLSKTVubiquitination[1]
20ISKNFLSKTVQAEPLubiquitination[1, 2]
36QDNPECLKMVISGMRubiquitination[1]
87SCRYFNPKDYSWTDIubiquitination[1]
134MDCYNVVKDSWYSKLubiquitination[1]
140VKDSWYSKLGPPTPRubiquitination[1]
188RTESWHTKPSMLTQRubiquitination[1, 3]
247CPMIEARKNHGLVFVubiquitination[1]
255NHGLVFVKDKIFAVGubiquitination[1]
279NVEYYDIKLNEWKMVubiquitination[3, 4]
292MVSPMPWKGVTVKCAubiquitination[1, 5]
335DKWVANSKVRAFPVTubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 361 AA 
Protein Sequence
MVDILAKVRF PLISKNFLSK TVQAEPLIQD NPECLKMVIS GMRYHLLSPE DREELVDGTR 60
PRRKKHDYRI ALFGGSQPQS CRYFNPKDYS WTDIRCPFEK RRDAACVFWD NVVYILGGSQ 120
LFPIKRMDCY NVVKDSWYSK LGPPTPRDSL AACAAEGKIY TSGGSEVGNS ALYLFECYDT 180
RTESWHTKPS MLTQRCSHGM VEANGLIYVC GGSLGNNVSG RVLNSCEVYD PATETWTELC 240
PMIEARKNHG LVFVKDKIFA VGGQNGLGGL DNVEYYDIKL NEWKMVSPMP WKGVTVKCAA 300
VGSIVYVLAG FQGVGRLGHI LEYNTETDKW VANSKVRAFP VTSCLICVVD TCGANEETLE 360
T 361 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF01344; Kelch_1 
SMART
 SM00612; Kelch 
PROSITE
  
PRINTS