UniProt Accession

 GMPR2_MOUSE; Q99L27; Q542X2; Q8R1T5 

Genbank Protein ID

 AK031004; AK075772; CH466535; BC003886; BC024109 

Genbank Nucleotide ID

 BAC27211.1; BAC35946.1; EDL36258.1; AAH03886.1; AAH24109.1 

Protein Name

 GMP reductase 2 

Protein Synonyms/Alias

 Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2 

Gene Name

 Gmpr2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	NDVKLDFKDVLLRPK	acetylation	[1, 2]
291	EYRASEGKIVEVPFK	acetylation	[3]
298	KIVEVPFKGDVEHTI	acetylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity). 

Sequence Annotation

 NP_BIND 108 131 NADP (By similarity).
 ACT_SITE 186 186 Thioimidate intermediate (By similarity).
 METAL 181 181 Potassium; via carbonyl oxygen (By
 METAL 183 183 Potassium; via carbonyl oxygen (By
 BINDING 219 219 NADP (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 348 AA 

Protein Sequence

Gene Ontology

 GO:0003920; F:GMP reductase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046038; P:GMP catabolic process; ISA:MGI.
 GO:0030224; P:monocyte differentiation; ISA:MGI. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR005993; GMP_reduct1.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 

Pfam

 PF00478; IMPDH 

SMART

  

PROSITE

 PS00487; IMP_DH_GMP_RED 

PRINTS