CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027390
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate--tRNA ligase, putative 
Protein Synonyms/Alias
  
Gene Name
 PF13_0257 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
360NPVLEDIKYEKSIIEacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 863 AA 
Protein Sequence
MIENTKVNIF YGNNKYPFIC KSILNVYKNK NKKILEKTET TVNVDENIKF IKDANVEELK 60
IEFLTNAPNN NNNNNNNNNN NNNNNNNNNN NINKGNMNHC GKNQEEEKKN LSKSNNIEKV 120
PYICSSDKIF AKILDHLLKT DLYNISEKID PKNNKVVNIY VQTQYEEWLD FFRSRNVNKD 180
IVFICEHLNK HLHLNTFVVS EYLTLSDIFI YFQMYKYFHV SSTQYAKYSK MYKNINRWHK 240
LIDSLIYFED AEWKKNLKCL ICDNKMNFDD RKDNLKNNNK SMNNTDDVKC KKKTVTTSYS 300
GKLENAVIGN VVTRFPPEPS GYLHVGHAKA AFLNNYYAQM YEGKMLLRFD DTNPVLEDIK 360
YEKSIIEDLE NLGLKYEKIS YSSDHFDLLE KYCIDMIKMN KAYADDTGVE DMRNQRGEGI 420
ESINRNNSIE KNLELFNEMR KGTEIGQKNC IRAKINMQSK NKCMRDPVMY RCIVDVPHHK 480
HQFKYKCYPT YDFACPIIDS IEGVTHALRT NEYSDRIEQY NWFISTLNLR KVYIYEFSRL 540
AFVKTVMSKR KLKWFVENNV VDSWVDPRFP TIKGILRRGL TKEALFQFIL EQGPSKAGNL 600
MQWDKLWSIN KQIIDPIIPR YAAVDKNSSI LLILTDLTDQ VIQKERDLHM KNKSLGTCNM 660
YYNNKYLIEL EDAQTLLENE EITLIKLGNI IIKNIEKENG KIKQINALSN FHGDFKTTKK 720
KIHWLPYLPQ QLITCTLYEY DHLITVDKFE NDNKDDWTNF INFNSKHETL VYAEPSISSL 780
KVSDKFQFER RGYFILDKID PHHHLHLIKI PDGKSKNMSI ITTKVDPKQL AGTKDTKDAK 840
DTKNTKDTKN TKDTKDTKNT KPN 863 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004818; F:glutamate-tRNA ligase activity; IEA:EC.
 GO:0006424; P:glutamyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR004526; Glu-tRNA-synth_Ib_arc/euk.
 IPR000924; Glu/Gln-tRNA-synth_Ib.
 IPR020061; Glu/Gln-tRNA-synth_Ib_a-bdl.
 IPR020058; Glu/Gln-tRNA-synth_Ib_cat-dom.
 IPR020059; Glu/Gln-tRNA-synth_Ib_codon-bd.
 IPR020056; Rbsml_L25/Gln-tRNA_synth_b-brl.
 IPR011035; Ribosomal_L25/Gln-tRNA_synth.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00749; tRNA-synt_1c
 PF03950; tRNA-synt_1c_C 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR00987; TRNASYNTHGLU.