CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoserine phosphatase 
Protein Synonyms/Alias
 PSP; PSPase; O-phosphoserine phosphohydrolase 
Gene Name
 serB 
Gene Synonyms/Alias
 b4388; JW4351 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
103LDVAPLGKIPHLRTPacetylation[1]
281ANDLPMIKAAGLGIAacetylation[1]
292LGIAYHAKPKVNEKAacetylation[1]
294IAYHAKPKVNEKAEVacetylation[1]
298AKPKVNEKAEVTIRHacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the dephosphorylation of phosphoserine (P- Ser). Also catalyzes the hydrolysis of phosphothreonine (P-Thr). 
Sequence Annotation
 REGION 10 12 Substrate (By similarity).
 REGION 204 205 Substrate binding (By similarity).
 ACT_SITE 116 116 Nucleophile (By similarity).
 ACT_SITE 118 118 Proton donor (By similarity).
 METAL 12 12 Magnesium (By similarity).
 METAL 116 116 Magnesium (By similarity).
 METAL 118 118 Magnesium; via carbonyl oxygen (By
 METAL 272 272 Magnesium (By similarity).
 BINDING 125 125 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 249 249 Substrate (By similarity).
 BINDING 275 275 Substrate (By similarity).  
Keyword
 Amino-acid biosynthesis; Complete proteome; Hydrolase; Magnesium; Metal-binding; Reference proteome; Serine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 322 AA 
Protein Sequence
MPNITWCDLP EDVSLWPGLP LSLSGDEVMP LDYHAGRSGW LLYGRGLDKQ RLTQYQSKLG 60
AAMVIVAAWC VEDYQVIRLA GSLTARATRL AHEAQLDVAP LGKIPHLRTP GLLVMDMDST 120
AIQIECIDEI AKLAGTGEMV AEVTERAMRG ELDFTASLRS RVATLKGADA NILQQVRENL 180
PLMPGLTQLV LKLETLGWKV AIASGGFTFF AEYLRDKLRL TAVVANELEI MDGKFTGNVI 240
GDIVDAQYKA KTLTRLAQEY EIPLAQTVAI GDGANDLPMI KAAGLGIAYH AKPKVNEKAE 300
VTIRHADLMG VFCILSGSLN QK 322 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0000287; F:magnesium ion binding; IDA:EcoliWiki.
 GO:0004647; F:phosphoserine phosphatase activity; IDA:EcoCyc.
 GO:0006564; P:L-serine biosynthetic process; IDA:EcoliWiki. 
Interpro
 IPR023214; HAD-like_dom.
 IPR006383; HAD-SF_hydro_IB_PSP-like.
 IPR023190; Pser_Pase_dom_2.
 IPR004469; SerB. 
Pfam
 PF00702; Hydrolase 
SMART
  
PROSITE
  
PRINTS