UniProt Accession

 A6NDI8_HUMAN; A6NDI8 

Genbank Protein ID

 AF196971 

Genbank Nucleotide ID

  

Protein Name

 Histone deacetylase 6 

Protein Synonyms/Alias

  

Gene Name

 HDAC6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	PERLHAIKEQLIQEG	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005881; C:cytoplasmic microtubule; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0004407; F:histone deacetylase activity; IEA:Compara.
 GO:0042903; F:tubulin deacetylase activity; IEA:Compara.
 GO:0070842; P:aggresome assembly; IEA:Compara.
 GO:0071218; P:cellular response to misfolded protein; IEA:Compara.
 GO:0016575; P:histone deacetylation; IEA:GOC.
 GO:0070846; P:Hsp90 deacetylation; IEA:Compara.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Compara.
 GO:0043241; P:protein complex disassembly; IEA:Compara.
 GO:0000209; P:protein polyubiquitination; IEA:Compara.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Compara. 

Interpro

 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom. 

Pfam

 PF00850; Hist_deacetyl 

SMART

  

PROSITE

  

PRINTS