UniProt Accession

 MAGG1_MOUSE; Q9CPR8; Q569V7; Q9D378 

Genbank Protein ID

 AF319979; AK010294; AK017727; AK018250; AK049759; AK076471; BC034892; BC092289 

Genbank Nucleotide ID

 AAK01207.1; BAB26830.1; BAB30899.1; BAB31133.1; BAC33907.1; BAC36358.1; AAH34892.1; AAH92289.2 

Protein Name

 Melanoma-associated antigen G1 

Protein Synonyms/Alias

 MAGE-G1 antigen; Necdin-like protein 2 

Gene Name

 Ndnl2 

Gene Synonyms/Alias

 Mageg1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
194	HLIFGDPKKLITEDF	acetylation	[1]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2s) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. 

Sequence Annotation

 DOMAIN 59 259 MAGE.
 REGION 52 279 Interaction with NSMCE1 (By similarity).
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 279 279 Phosphoserine (By similarity).  

Keyword

 Chromosome; Complete proteome; Cytoplasm; DNA damage; DNA recombination; DNA repair; Growth regulation; Nucleus; Phosphoprotein; Reference proteome; Telomere; Tumor antigen; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030915; C:Smc5-Smc6 complex; ISS:UniProtKB.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. 

Interpro

 IPR002190; MAGE. 

Pfam

 PF01454; MAGE 

SMART

  

PROSITE

 PS50838; MAGE 

PRINTS