CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 358 
Protein Synonyms/Alias
  
Gene Name
 ZNF358 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
280GQGSALLKHLRTHTGubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 151 173 C2H2-type 1.
 ZN_FING 179 201 C2H2-type 2.
 ZN_FING 207 229 C2H2-type 3.
 ZN_FING 235 257 C2H2-type 4.
 ZN_FING 263 285 C2H2-type 5.
 ZN_FING 291 313 C2H2-type 6.
 ZN_FING 319 341 C2H2-type 7.
 ZN_FING 347 369 C2H2-type 8.
 ZN_FING 375 397 C2H2-type 9.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL NTVPEDVDPS 60
YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG PVPLILDPNS DTLSPGDPKV 120
DPISSGLTAT PQVLATSPAV LPAPASPPRP FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR 180
CPDCGKSFSH GATLAQHRGI HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC 240
GKAFGHGSLL AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF 300
GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP HCSKAFGQSS 360
ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA AAAAAAAAAA AAAAAAGLGL 420
GPGLSPASMM RPGQVSLLGP DAVSVLGSGL GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP 480
GSRSTPSPTP VESSDPKAGH DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT 540
RGTVSPALPT GESPEWVQEQ GALLGPDG 568 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0035115; P:embryonic forelimb morphogenesis; ISS:UniProtKB.
 GO:0021915; P:neural tube development; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019827; P:stem cell maintenance; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS