UniProt Accession

 DLRB1_HUMAN; Q9NP97; B1AKR5; Q5TC72; Q96IV3; Q9NQM2 

Genbank Protein ID

 AF132750; AF165516; AF178431; AY026513; AF161511; AL109923; AL136173; AL136173; AL109923; AL109923; AL136173; AL136173; AL109923; BC002481; BC007223 

Genbank Nucleotide ID

 AAL75951.1; AAF86646.1; AAK95342.1; AAK18712.1; AAF29126.1; CAI21456.1; CAI21456.1; CAI23308.1; CAI23308.1; CAM28250.1; CAM28250.1; CAM28343.1; CAM28343.1; AAH02481.1 

Protein Name

 Dynein light chain roadblock-type 1 

Protein Synonyms/Alias

 Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; Roadblock domain-containing protein 1 

Gene Name

 DYNLRB1 

Gene Synonyms/Alias

 BITH; DNCL2A; DNLC2A; ROBLD1; HSPC162 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	LKRLQSQKGVQGIIV	ubiquitination	[1, 2]
52	LMHSFILKARSTVRD	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Microtubule; Motor protein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 96 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; NAS:UniProtKB.
 GO:0007018; P:microtubule-based movement; NAS:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0007632; P:visual behavior; ISS:UniProtKB. 

Interpro

 IPR004942; Dynein_light-rel.
 IPR016561; Dynein_light_roadblock-type. 

Pfam

 PF03259; Robl_LC7 

SMART

 SM00960; Robl_LC7 

PROSITE

  

PRINTS