UniProt Accession

 GPN1_HUMAN; Q9HCN4; B4DQJ5; B4DXU4; B5MBZ5; O76004 

Genbank Protein ID

 AB044661; AK298827; AK302131; AK310340; AK316404; AC074091; BC007451; AJ010842 

Genbank Nucleotide ID

 BAB17612.1; BAG60957.1; BAG63506.1; BAH14775.1; AAH07451.1; CAA09376.1 

Protein Name

 GPN-loop GTPase 1 

Protein Synonyms/Alias

 MBD2-interacting protein; MBDin; XPA-binding protein 1 

Gene Name

 GPN1 

Gene Synonyms/Alias

 MBDIN; XAB1; HUSSY-23 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	RPEYERLKKSLANAE	ubiquitination	[1]
278	PEYERLKKSLANAES	ubiquitination	[1, 2]
297	EQLERLRKDMGSVAL	ubiquitination	[1, 3]
310	ALDAGTAKDSLSPVL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. 

Sequence Annotation

 NP_BIND 26 33 GTP (Pootential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 312 312 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.
 MOD_RES 338 338 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR004130; Uncharacterised_ATP-bd. 

Pfam

 PF03029; ATP_bind_1 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS