CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DBIRD complex subunit KIAA1967 homolog 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
347EHPLKQLKFLLGRKEubiquitination[1]
908EMQRIVEKADSWVEKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (By similarity). As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Inhibits SUV39H1 methyltransferase activity. 
Sequence Annotation
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 215 215 N6-acetyllysine (By similarity).
 MOD_RES 612 612 Phosphoserine.
 MOD_RES 674 674 Phosphoserine.
 MOD_RES 677 677 Phosphoserine.
 MOD_RES 680 680 Phosphoserine.  
Keyword
 Acetylation; Apoptosis; Coiled coil; Complete proteome; Direct protein sequencing; Metalloenzyme inhibitor; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 922 AA 
Protein Sequence
MSQFKRQRIN PLPGGRNFSG AASTSLLGPP PGLLTPPVAT DLSQNARHLQ SGEKQRVFTG 60
IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY NPGQAVPWNA VKVQTLSNQP 120
LLKSPAPPLL HVAALGQKQG ILGAQPQLIF QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR 180
FPARGPHGRL DQGRSDDYDS KKRKQRAGGE PWGAKKPRHD LSPYRVHLTP YTVDSPTCDF 240
LELQRRYRSL LVPSDFLSVH LSWLSAFPLG QPFSLHHPSR IQVSSEKEAA PDTGAEPSPE 300
DSDPTYSSKV LLLSSPGLEE FYRCCMLFVD DMAEPRETPE HPLKQLKFLL GRKEEEAVLV 360
GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSTCT KWWRFAEFQY LQPGPPRQLH 420
TVVVYLPDVW TIMPTLEEWE ALCQQKATEA APQPHEASGE AEATEQAPDV SEQADTSKQN 480
TETMEATTQQ DVDTDLPEAP PPPLEPAVMA RPRCVNLSLY GIVEDRRPKE RISFEVVVLA 540
ELFVEMLQRD FGYRIYKTLL SLPEKVVSPP EPEKEEAAKE DAVKEEEAVK EEAVKVSKDE 600
VQNEGTAAES DSPLKEDGLL PKRPSSGGEE EEKARGEAAE DLCEMALDPD LLLLRDDGED 660
EFAGAKLEET EVRSVASNQS EMEYSSLQDM PKELDPSTVL PLDCLLAFVF FDANWCGYLH 720
RRDLERVLLT LGIRLSAEQA KQLVSRVVAQ NICQYRSLQY SRAEVLDDGL PEDVLFGNLD 780
LLPPSGKSTK PGAAPTEHKG LVPHNGSLIN VGSLLQRAEQ QDSGRLYLEN KIHTLELKLE 840
ESHNRFSATE VTNKTLAAEM QELRARLAEA EETARTAERQ KNQLQRQMQD FRRRLTPLHL 900
EMQRIVEKAD SWVEKEEPTP SN 922 
Gene Ontology
 GO:0044609; C:DBIRD complex; ISS:UniProtKB.
 GO:0005759; C:mitochondrial matrix; IEA:Compara.
 GO:0005681; C:spliceosomal complex; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IDA:UniProtKB.
 GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; ISS:UniProtKB. 
Interpro
 IPR025224; DBC1/CARP1.
 IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
 IPR025223; S1-like_RNA-bd_dom. 
Pfam
 PF14443; DBC1
 PF14444; S1-like 
SMART
  
PROSITE
  
PRINTS