Tag | Content |
---|
CPLM ID | CPLM-038280 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein Herc1 |
Protein Synonyms/Alias | |
Gene Name | Herc1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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2767 | FSLRQIAKAMEATGA | ubiquitination | [1] | 2879 | STVTRRHKFDLAART | ubiquitination | [1] | 3309 | VDDPIQRKFLPSFLR | ubiquitination | [1] | 3353 | KLRPNYDKTEIEKKG | ubiquitination | [1] | 3458 | RVWNVTKKQYSLQQT | ubiquitination | [1] | 3835 | ATCRTALKQQGVLGL | ubiquitination | [1] | 4466 | GKTMVQGKNYGPQIT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4859 AA |
Protein Sequence | MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVTVLYSK LISNKEVVPL PQQVLCLKGP 60 QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120 YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP 180 VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD 240 TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVYT MEKNKLLSSQ EGMISFDCFM 300 AILMQMRRSL GSSADRSQWR EPTRTSEGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI 360 QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST 420 DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF 480 SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF 540 GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 600 RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE 660 ELAATRIVDI SIGDSHCLSL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI 720 QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP 780 FPSSREHHNF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE 840 VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 900 SLLGYSSPSD AADLSTVCMG YGNLSDQPYG SQICHPDTHL AEILMKTLLR NLGFYTDQAF 960 GELEKNSDKY LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNVTENSS SVALLHKHLQ 1020 LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP 1080 LLSYLLDLLP PLDCLNRLLP AAALLEDQEL QWPLHGGPEV IDPAGVPLPQ PAQSWVWLVD 1140 LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 1200 LSGNEEQKPF DYKLRPEVAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL 1260 DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS 1320 SSRDRWITDN QDSADVDPQE HSFTRTIDEE AEMEELAERD REDGHPEPED EEEEREHEVM 1380 TAGKIFQCFL SAREVARSRD RDRMNSGAGS GVRADDPPPQ SQQERRVSTD LPEGQDVYTA 1440 ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSVSAS EGTGLMTRSE SLTAESRLVH 1500 ASPSYRLIKS RSESDLSQPE SDEEGYALSG RRNVDFDLAS SHRKRGPMHS QLESLSDSWT 1560 RLKHTRDWFY NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP 1620 QASIIAMEQQ QLRAELRLEA LHQILTLLSG MEEKGNVLLT GSRSSSGFQS STLLTSVRLQ 1680 FLAGCFGLGT VGHTGTKGES GRLHHYQDGI RAAKRNIQVE IQVAVHKIYQ QLSATLERAL 1740 QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 1800 KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQTGVLF 1860 MASFGEGEEG EEEEKKVDSS GEAEKRDFRA ALRKQHAAEL HLGDFLVFLR RVVSSKAIQS 1920 KMASPKWTEV LLNIASQKCS SGIPLVGNLR TRLLALHVLE AVLPACESGV EDDQMAQVVE 1980 RLFSLLSDCM WETPIAQAKH AIQIKEKEQE IKLQKQGELE EEDENLPIQE VSFDPEKAQC 2040 CIVENGQILT HGSGGKGYGL ASTGVTSGCY QWKFYIVKEN RGNEGTCVGV SRWPVHDFNH 2100 RTTSDMWLYR AYSGNLYHNG EQTLTLSSFT QGDFITCVLD MEARTISFGK NGEEPKLAFE 2160 DVDAAELYPC VMFYSSNPGE KVKICDMQMR GTPRDLLPGD PICSPVAAVL AEATIQLIRI 2220 LHRTDRWTYC INKKMMERLH KIKICIKESG QKLKKSRSVQ SREENEMREE KENKEEEKGK 2280 HNRHGLADLS EPQLRTLCIE VWPVLAVIGG VDAGLRVGGR CVHKQTGRHA TLLGVVKEGS 2340 TSAKVQWDEA EITISFPTFW SPSDTPLYNL EPCEPLLFDV ARFRGLTASV LLDLTYLTGI 2400 HEDVGKQSIK RHEKKHRHES EEKGDIEQKP ESESILDVRT GLMSDDVKSQ GTTSSKSENE 2460 IASFSLEPTL PGVESQHQIT EGKRKNHEHI SKTHDIAQSE IRAVQLSYLY LGAMKSLSAL 2520 LGCSKYAELL LIPKVLAENG HNSDCASSPV VHEDVEMRAA LQFLMRHMVK RAVMRSPIKR 2580 ALGLADLERA QAMIYKLVVH GLLEDQFGGK IKQEIDQQAE ESDQAQQAQT PVTTSPSASS 2640 TTSFMSSSLE DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT VLPTRRAQTP 2700 PISSLPASPS DEVGRRQSLT SPDSQSTRPA NRTALSDPSS RLSTSPPPPA IAVPLLEMGF 2760 SLRQIAKAME ATGARGEADA QSITVLAMWM IEHPGHEDEE EPQPSSTADS RHGATVLGSG 2820 GKSNDPCYLQ SPGDIPSADA AEMEEGFSES PDNLDHTENA ASGSGPPTRG RSTVTRRHKF 2880 DLAARTLLAR AAGLYRSVQA HRNQSRREGI SLQQDPGALY DFNLDEELEI DLDDEAMEAM 2940 FGQDLTSDND ILGMWIPEVL DWPTWHVCES EDREEVVVCE LCECNVVSFN QHMKRNHPGC 3000 GRSANRQGYR SNGSYVDGWF GGECGSGNPY YLLCGSCREK YLALKTKTKT TNSERYKGQA 3060 PDLIGKQDSV YEEDWDMLDV DEDEKLTGEE EFELLAGPLG LNDRRIVPEP VQFPDSDPLG 3120 ASVAMVTATN SMEETLMQIG CHGSVEKSSS GRVTLGEQAA ALANPHDRVV ALRRVTAAAQ 3180 VLLARTMVMR ALSLLSVSGS SCSLAAGLES LGLTDIRTLV RLMCLAAAGR AGLSTSPSAI 3240 ASTSERSRGG HSKASKPISC LAYLSTAVGC LASNTPSAAK LLVQLCTQNL ISAATGVNLT 3300 TVDDPIQRKF LPSFLRGIAE ENKLVTSPNF VVTQALVALL ADKGAKLRPN YDKTEIEKKG 3360 PLELANALAA CCLSSRLSSQ HRQWAAQQLV RTLAAHDRDN QTAPQTLADM GGDLRKCSFI 3420 KLEAHQNRVM TCVWCNKKGL LATSGNDGTI RVWNVTKKQY SLQQTCVFNR LEGDAEESLG 3480 SPSDPSFSPV SWSISGKYLA GALEKMVNIW QVNGGKGLVD IQPHWVSALA WPEEGPATTW 3540 SGESPELLLV GRMDGSLGLI EVVDVSTMHR RELEHCYRKD VSVTCIAWFS EDRPFAVGYF 3600 DGKLLMGTKE PLEKGGIVLI DAHKETLVSM KWDPTGHILM TCAKEENVKL WGPVSGCWRC 3660 LHSLCHPSTV NGIAWCSLPG KGSKMQLLMA TGCQNGLVCV WRIPQDTTQT SMTSSEGWWD 3720 QESNCQDGYR KSAGAKCVYQ LRGHITPVRT VAFSSDGLAL VSGGLGGLMN IWSLRDGSVL 3780 QTVVIGSGAI QTTVWIPEVG VAACSNRSKD VLVVNCTAEW ASANHILATC RTALKQQGVL 3840 GLNMAPCMRA FLERLPMMLQ EQYAYEKPHV VCGDQLVHSP YMQCLASLAV GLHLDQLLCN 3900 PPVPPHHQNC LPDPTSWNPN EWAWLECFST TIKAAEALTN GAQFPESFTV PDLEPVPEDE 3960 LVLLMDNSKW INGMDEQIMS WATSRPEDWH LGGKCDVYLW GAGRHGQLAE AGRNVMVPAT 4020 APSFSQAQQV ICGQNCTFVI QANGTVLACG EGSYGRLGQG NSDDLHVLTV ISALQGFVVT 4080 QLVTSCGSDG HSMALTESGE VFSWGDGDYG KLGHGNSDRQ RRPRQIEALQ GEEVVQMSCG 4140 FKHSAVVTSD GKLFTFGNGD YGRLGLGNTS NKKLPERVTA LEGYQIGQVA CGLNHTLAVS 4200 ADGSMVWAFG DGDYGKLGLG NSTAKSSPQK VDVLCGIGIK KVACGTQFSV ALTKDGHVYT 4260 FGQDRLIGLP EGRARNHNRP QQIPVLAGVV IEDVAVGAEH TLALASTGDV YAWGSNSEGQ 4320 LGLGHTNHVR EPTLVTVLQG KNIRQISAGR CHSAAWTAPP VPPRAPGVSV PLQLGLPDAV 4380 PPQYGALREV SIHTVRARLR LLYHFSDLMY SSWRLLNLSP NNQNSTSHYN AGTWGIVQGQ 4440 LRPLLAPRVY TLPMVRSIGK TMVQGKNYGP QITVKRISTR GRKCKPIFVQ IARQVVKLNA 4500 SDLRLPSRAW KVKLVGEGAD DAGGVFDDTI TEMCQELETG IVDLLIPSPN ATAEVGYNRD 4560 RFLFNPSACL DEHLMQFKFL GILMGVAIRT KKPLDLHLAP LVWKQLCCVP LTLEDLEEVD 4620 LLYVQTLNSI LHIEDSGITE ESFHEMIPLD SFVGQSADGK MVPIIPGGNS IPLTFSNRKE 4680 YVERAIEYRL HEMDRQVAAV REGMSWIVPV PLLSLLTAKQ LEQMVCGMPE ICVDVLKKVV 4740 RYREVDEQHQ LVQWLWRTLE EFSNEERVLF MRFVSGRSRL PANTADISQR FQIMKVDRPY 4800 DSLPTSQTCF FQLRLPPYSS QLVMAERLRY AINNCRSIDM DNYMLSRNVD NAEGSDTDY 4859 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI. GO:0010507; P:negative regulation of autophagy; IMP:MGI. GO:0050885; P:neuromuscular process controlling balance; IMP:MGI. GO:0031175; P:neuron projection development; IMP:MGI. GO:0016567; P:protein ubiquitination; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |