UniProt Accession

 A2AMW0_MOUSE; A2AMW0 

Genbank Protein ID

 AL807811; CH466615 

Genbank Nucleotide ID

 EDL13296.1 

Protein Name

 Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a 

Protein Synonyms/Alias

 F-actin-capping protein subunit beta 

Gene Name

 Capzb 

Gene Synonyms/Alias

 mCG_122335 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	PLKIARDKVVGKDYL	acetylation	[1]
45	ARDKVVGKDYLLCDY	acetylation	[1]
66	YRSPWSNKYDPPLED	acetylation	[1, 2, 3]
66	YRSPWSNKYDPPLED	ubiquitination	[4]
83	MPSARLRKLEVEANN	acetylation	[1, 3]
83	MPSARLRKLEVEANN	ubiquitination	[4]
133	GDGSKKIKGCWDSIH	acetylation	[1]
147	HVVEVQEKSSGRTAH	acetylation	[2]
147	HVVEVQEKSSGRTAH	ubiquitination	[4]
187	SLTRQMEKDETVSDC	acetylation	[1, 3]
211	LVEDMENKIRSTLNE	acetylation	[2]
211	LVEDMENKIRSTLNE	ubiquitination	[4]
223	LNEIYFGKTKDIVNG	acetylation	[1, 3]
223	LNEIYFGKTKDIVNG	succinylation	[3]
223	LNEIYFGKTKDIVNG	ubiquitination	[4]
225	EIYFGKTKDIVNGLR	ubiquitination	[4]
240	SVQTFADKSKQEALK	acetylation	[3]
240	SVQTFADKSKQEALK	ubiquitination	[4]
242	QTFADKSKQEALKND	ubiquitination	[4]
247	KSKQEALKNDLVEAL	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0008290; C:F-actin capping protein complex; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0071203; C:WASH complex; IEA:InterPro.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051016; P:barbed-end actin filament capping; IDA:MGI.
 GO:0030032; P:lamellipodium assembly; IMP:MGI.
 GO:0048747; P:muscle fiber development; IMP:MGI.
 GO:0031115; P:negative regulation of microtubule polymerization; IDA:MGI.
 GO:0031175; P:neuron projection development; IMP:MGI.
 GO:0090036; P:regulation of protein kinase C signaling cascade; IMP:MGI. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.