CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HAUS augmin-like complex subunit 6 
Protein Synonyms/Alias
  
Gene Name
 HAUS6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53RQDCVTQKYQENAQLubiquitination[1]
63ENAQLSVKQVRNLRSubiquitination[1, 2, 3, 4, 5]
80IGLENQIKKMEPYDDubiquitination[1, 5]
81GLENQIKKMEPYDDHubiquitination[1, 5]
147IPRLLLDKIEKQMFQubiquitination[1, 2]
203VDLHYLEKETKFQKEubiquitination[1, 5]
216KERLSDLKHMRYRIKubiquitination[1, 2]
223KHMRYRIKDDLTTIRubiquitination[1, 5]
236IRHSVVEKQGEWHKKubiquitination[1]
245GEWHKKWKEFLGLSPubiquitination[1]
423SPQLSEGKEIKLEELubiquitination[2]
472EMEENRTKEPIQMDAubiquitination[2]
532DCECVPQKHVLTSHIubiquitination[1, 5]
553NQSDLLNKKVICKQDubiquitination[1, 2]
554QSDLLNKKVICKQDLubiquitination[1]
558LNKKVICKQDLECLAubiquitination[1, 5]
568LECLAFTKLSETSRMubiquitination[1, 5]
598GSEEEFMKILDHLEVubiquitination[1]
609HLEVSCNKPSTNKTMubiquitination[1, 5]
711LKKSLSKKREESYLSubiquitination[1, 2, 5]
727SQTPERHKPELSPTPubiquitination[1]
757DLHTEHIKPSLRTSIubiquitination[1]
776RSLSPLIKFSPVEQRubiquitination[1, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 802 AA 
Protein Sequence
MKYIKSNSKN SSHHFVETFN IKPQDLHKCI ARCHFARSRF LQILQRQDCV TQKYQENAQL 60
SVKQVRNLRS ECIGLENQIK KMEPYDDHSN MEEKIQKVRS LWASVNETLM FLEKEREVVS 120
SVLSLVNQYA LDGTNVAINI PRLLLDKIEK QMFQLHIGNV YEAGKLNLLT VIQLLNEVLK 180
VMKYERCQAD QARLTVDLHY LEKETKFQKE RLSDLKHMRY RIKDDLTTIR HSVVEKQGEW 240
HKKWKEFLGL SPFSLIKGWT PSVDLLPPMS PLSFDPASEE VYAKSILCQY PASLPDAHKQ 300
HNQENGCRGD SDTLGALHDL ANSPASFLSQ SVSSSDRNSV TVLEKDTKMG TPKEKNEAIS 360
KKIPEFEVEN SPLSDVAKNT ESSAFGGSLP AKKSDPFQKE QDHLVEEVAR AVLSDSPQLS 420
EGKEIKLEEL IDSLGSNPFL TRNQIPRTPE NLITEIRSSW RKAIEMEENR TKEPIQMDAE 480
HREVLPESLP VLHNQREFSM ADFLLETTVS DFGQSHLTEE KVISDCECVP QKHVLTSHID 540
EPPTQNQSDL LNKKVICKQD LECLAFTKLS ETSRMETFSP AVGNRIDVMG GSEEEFMKIL 600
DHLEVSCNKP STNKTMLWNS FQISSGISSK SFKDNDFGIL HETLPEEVGH LSFNSSSSSE 660
ANFKLEPNSP MHGGTLLEDV VGGRQTTPES DFNLQALRSR YEALKKSLSK KREESYLSNS 720
QTPERHKPEL SPTPQNVQTD DTLNFLDTCD LHTEHIKPSL RTSIGERKRS LSPLIKFSPV 780
EQRLRTTIAC SLGELPNLKG KV 802 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0070652; C:HAUS complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0051297; P:centrosome organization; IEA:InterPro.
 GO:0051225; P:spindle assembly; IEA:InterPro. 
Interpro
 IPR026797; HAUS_6. 
Pfam
  
SMART
  
PROSITE
  
PRINTS